cytokines and autism

The Th17–IL-17–IL-17R System Linked To Altered Brain Development and Autism-Like Symptoms in Mice

The Th17–IL-17–IL-17R System Linked To Altered Brain Development and Autism-Like Symptoms in Mice

A new report published in Science indicates that the key pro-inflammatory cytokine interleukin (IL)-17a may interfere with the normal brain development in a mouse model of autism, causing disorganized cortical cytoarchitecture and autism-like symptoms. IL-17 is a highly pathogenic pro-inflammatory cytokine, considered a major player in several autoimmune/inflammatory diseases, whereas altered cytokine profiles and increased […]

High Neonatal Monocyte Chemotactic Protein-1 (MCP-1) Levels May Represent an Early Marker of Autism

High Neonatal Monocyte Chemotactic Protein-1 (MCP-1) Levels May Represent an Early Marker of Autism

A study published in the Journal of Neuroinflammation indicates that the chemokine monocyte chemotactic protein-1 (MCP-1) may represent an early marker for ASD. Immune dysregulation and markers of inflammation have been associated with Autism Spectrum Disorder (ASD). Yet, most of the prior studies have used specimens taken after clinical diagnosis, and even with the relatively […]

Immune & Cytokine Dysregulation Associated With Behavioral Deficits In A Mouse Model Of Autism

Immune & Cytokine Dysregulation Associated With Behavioral Deficits In A Mouse Model Of Autism

A new report in the Proceedings of the National Academy of Sciences of the USA (PNAS) indicates that cellular and cytokine immune dysregulation may contribute to the autism spectrum disorder (ASD)-related behavioral deficits in a mouse model of an autism. Recent evidence indicates the involvement of an abnormal immune system activity in the pathogenesis of […]

Cytokine Profiles in Subjects with Autism Spectrum Disorders

Cytokine Profiles in Subjects with Autism Spectrum Disorders

In a study published in the online journal PLoS ONE, a research group from the Hamamatsu University School of Medicine, Hamamatsu, Japan reports the presence of high levels of several pro-inflammatory cytokines in male (≥6 years old) subjects with autism spectrum disorder (ASD). ASD include autistic disorder, Asperger’s disorder and pervasive developmental disorder. A dysregulation […]