chronic fatigue syndrome

Understanding the Role of Inflammation in Fatigue Requires Multidimensional Assessments

Understanding the Role of Inflammation in Fatigue Requires Multidimensional Assessments

Evolving concepts Introduction “I am tired”. What does this sentence actually imply? In a recent review published in Frontiers in Immunology [1], we suggest that the different dimensions of fatigue (Figure 1) should be specifically investigated, in subjective as well as objective ways. This is especially important if we are to comprehend the role of […]

High Blood Interferon-γ Levels Linked to the Early Phase of Chronic Fatigue Syndrome

High Blood Interferon-γ Levels Linked to the Early Phase of Chronic Fatigue Syndrome

A study published in the February issue of the new journal Science Advances is perhaps the first to identify distinct stages of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Importantly, it demonstrates some immune signatures early in the course of ME/CFS that are not present in subjects with longer duration of illness. Although efforts were made to […]

Deficiency of IL-10 in Chronic Fatigue Syndrome?

Deficiency of IL-10 in Chronic Fatigue Syndrome?

A new 2015 study, published in the Mediators of Inflammation journal suggests a deficiency of interleukin (IL)-10 in chronic fatigue syndrome (CFS). Chronic fatigue syndrome/myalgic encephalomyelitis, an illness characterized by unexplained fatigue lasting 6 months or more, is often linked to dysfunctional neuroendocrine and immune responses, including abnormal production of several cytokines (NG Klimas & […]