cardiovascular disease

First Evidence that IL-9 Contributes to Atherosclerosis Development

First Evidence that IL-9 Contributes to Atherosclerosis Development

Perhaps the first evidence for an involvement of IL-9 in atherosclerosis was recently reported in the online journal PLoS One by Ida Gregersen and colleagues from the Oslo University Hospital Rikshospitalet, Oslo, Norway. Interleukin (IL)-9 is a cytokine linked mostly to T helper (Th)2 cell responses and Th2-related conditions such as parasitic helminth infections and […]

Colchicine May Prove Useful In the Treatment of Acute Coronary Syndrome

Colchicine May Prove Useful In the Treatment of Acute Coronary Syndrome

A study by Gonzalo Martınez et al., published in the Journal of the American Heart Association indicates that colchicine may also be useful for the treatment of heart attacks by reducing cardiac inflammation and the local pro-inflammatory cytokine production. Colchicine is an alkaloid with potent anti-inflammatory effects, which is often used for the treatment of […]

Evidence that Napping May Correct Interleukin-6 Changes and the Stress Induction Caused By Sleep Deprivation

Evidence that Napping May Correct Interleukin-6 Changes and the Stress Induction Caused By Sleep Deprivation

A study published in the March issue of The Journal of Clinical Endocrinology & Metabolism (JCEM) indicates that short-term napping is able to restore, to a great extent, the neurohormonal and immune changes induced by sleep deprivation. Insufficient sleep is well-known to be associated with poor attention and performance deficits. However, an increasing body of […]

Short Breastfeeding Duration and Low Birth Weight Linked To High Adulthood CRP Levels: Implications for Cardiovascular Disease Risk

Short Breastfeeding Duration and Low Birth Weight Linked To High Adulthood CRP Levels: Implications for Cardiovascular Disease Risk

A recent study by Thomas McDade and colleagues from the Northwestern University, IL, USA, suggests that lower birth weight babies breastfed less than three months, or not at all, are more likely as young adults to have higher levels of chronic inflammation. Systemic inflammation plays a major pathogenic role in cardiovascular (CV) diseases, insulin resistance, […]

The Emerging Role of Innate Immune Cells’ Network and the Cardio-Splenic Axis in Heart Failure

The Emerging Role of Innate Immune Cells’ Network and the Cardio-Splenic Axis in Heart Failure

A new study published in the journal Circulation Research is perhaps the first to show changes of the innate cells network and traffic in ischemic heart failure. Heart failure (HF) remains a major health issue, and evidence accumulated over the last decade has established immune activation or inflammation as a major pathogenic factor in chronic […]

Interleukin-6 – a Better Predictor of Future Cardiovascular Events Than C-Reactive Protein?

Interleukin-6 – a Better Predictor of Future Cardiovascular Events Than C-Reactive Protein?

In a study published in the journal Cytokine, Hidenori Nishida and colleagues from the National Cerebral and Cardiovascular Center, Suita, Japan, demonstrate that an increased level of serum IL-6 is a significant predictor of future cardiovascular (CV) events in high-risk Japanese patients, independently of a variety of influencing factors. One of the paradigm shifts in […]

Negative and Competitive Interpersonal Stressors Linked to High Proinflammatory Cytokine Responses

Negative and Competitive Interpersonal Stressors Linked to High Proinflammatory Cytokine Responses

In a recent PNAS study, Jessica Chiang and colleagues from the Department of Psychology, David Geffen School of Medicine, University of California, Los Angeles, investigated the potential importance of negative, competitive and positive daily interactions on inflammatory activity. The authors of this study demonstrate that negative social interactions significantly predicted higher baseline levels of sTNFaRII […]

Inflammation Causing Hypertension: A New Concept Reviewed

Inflammation Causing Hypertension: A New Concept Reviewed

In a recent review article David Harrison and colleagues from the Department of Medicine, Vanderbilt University, Nashville, TN, summarize recent animal and human studies suggesting that inflammation and adaptive immunity responses are implicated in the pathogenesis of hypertension. As stated by the authors, quote: “A prominent pathology textbook used in the United States includes an […]

Elevated Plasma IL-10 Levels are a Strong Predictor of Long-Term Adverse Outcomes in Acute Coronary Syndrome

Elevated Plasma IL-10 Levels are a Strong Predictor of Long-Term Adverse Outcomes in Acute Coronary Syndrome

Interleukin (IL)-10 is often considered as a ‘cardioprotective’ cytokine, but a recent study published in the American Journal of Medicine reports an ‘unexpected’ observation that elevated baseline plasma levels of IL-10 are a strong predictor of long-term adverse cardiovascular outcomes in patients with acute coronary syndrome. Interleukin-10 is an immunoregulatory cytokine with strong anti-inflammatory properties. […]

Stress, Immunity and Coronary Artery Disease

Stress, Immunity and Coronary Artery Disease

In this review Roger Ho and colleagues discuss how stress hormones through affecting different components of the immune/inflammatory reaction may in turn contribute to the development of coronary artery disease (CAD). Recent evidence indicates that acute and chronic psychological stress, such as intense anger, low socioeconomic status, work stress, social isolation, depression, anxiety and hostility […]

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