cancer

Interleukin-35 Restrains Lymphocytic Infiltration and T Cell-Dependent Anti-Tumor Immunity

Interleukin-35 Restrains Lymphocytic Infiltration and T Cell-Dependent Anti-Tumor Immunity

A new study published in the journal Immunity indicates that interleukin (IL)-35 inhibits the recruitment of effector anti-tumor T cells and suppresses their function in the tumor microenvironment. IL-35 belongs to the IL-12 family of cytokines. It is a dimeric protein composed of two subunits – p35 and EBI3, which are shared with other IL-12 […]

Significant Progress in Understanding How Immunotherapy Works And How the Immune System Recognizes Cancer

Significant Progress in Understanding How Immunotherapy Works And How the Immune System Recognizes Cancer

A new study published in the New England Journal of Medicine has identified a mechanism that may explain why ipilimumab controls melanoma in only some people. The study also provides new important insights on the identity of molecules, on the surface of cancer cells, which allow the body’s immune system to identify and destroy them. […]

Cool Housing Temperature and Cold Stress Linked To Immunosuppression and Increased Tumor Growth in Experimental Animals

Cool Housing Temperature and Cold Stress Linked To Immunosuppression and Increased Tumor Growth in Experimental Animals

In the December 2013 issue of the Proceedings of the National Academy of Sciences of the USA Kathleen Kokolus et al., from the Roswell Park Cancer Institute, Buffalo, NY and the US Environmental Protection Agency, NC, demonstrate that a cool ambient housing temperature may affect the outcome of a broad range of experimental endpoints, including […]

Autonomic Nerves May Contribute to Prostate Cancer Development

Autonomic Nerves May Contribute to Prostate Cancer Development

In the July 2013 issue of Science magazine, Claire Magnon et al. provide evidence that autonomic nerves contribute to prostate cancer development, where the sympathetic nervous system (SNS) via the activation of β2 and β3-adrenergic receptor pathway participate in the early phase of tumor development. On the other hand, the parasympathetic (cholinergic) nervous system plays […]

How T cells kill cancer cells at the cytotoxic immune synapse

How T cells kill cancer cells at the cytotoxic immune synapse

A new report published in The Journal of Immunology identifies the spatiotemporal events, and the role of calcium flux and the degranulation of cytotoxic lymphocytes in the process of rapid formation by these cells of immune synapses and the killing of their target cells. The cytotoxic lymphocytes (CLs) destroy virus-infected and malignant cells via an […]

Beta Blockers Improve Survival in Ovarian Cancer Patients

Beta Blockers Improve Survival in Ovarian Cancer Patients

At a recent meeting of the American Society of Gynecologic Oncology in Los Angeles, CA., Anil Sood, MD, and colleagues from the MD Anderson Cancer Center in Houston, reported that patients with advanced ovarian cancer had significantly better survival if they took beta blockers. In the past few years, more than a dozen studies have […]

Neurotensin and Its Receptors in B Cells: Implications for Chronic B Cell Lymphocytic Leukemia

Neurotensin and Its Receptors in B Cells: Implications for Chronic B Cell Lymphocytic Leukemia

A new study in Journal of Immunology by Sofiane Saada and colleagues from the Department of Immunology, University of Limoges, Limoges, France is the first to report the expression of neurotensin and its high NTSR1 and low NTSR2-affinity receptors in human B cell lines, primary malignant B cells from chronic B cell lymphocytic leukemia (CLL) […]

Psychological Distress Is Dose-Dependently Related to Increased Mortality

Psychological Distress Is Dose-Dependently Related to Increased Mortality

A recent study published in the 2012 July issue of the British Medical Journal is probably the largest so far to show that a dose-response association exists between psychological distress and major causes of mortality across the full range of distress. Psychological stress has been linked to the development and progression of several common human […]

Microbial Deprivation, Inflammation and the Th17/IL-23 Axis in Cancer Development

Microbial Deprivation, Inflammation and the Th17/IL-23 Axis in Cancer Development

In a recent review article in Cancer and Metastasis Reviews Leena von Hertzen, H. Joensuu and T. Haahtela, from the Skin and Allergy Hospital, Helsinki University Central Hospital, Finland, summarize the epidemiological data related to microbe-rich environments and cancer, and discuss the involvement of the T helper (Th)17/Interleukin(IL)-23 axis and the immunomodulatory potential of environmental microbiota […]

Stress May Restrain the Immunostimulatory Effects of Interleukin-12

Stress May Restrain the Immunostimulatory Effects of Interleukin-12

A new study published in the journal Brain, Behavior, and Immunity suggests that chronic stress exposure can abolish the effects of immunostimulatory treatments such as the administration of interleukin (IL)-12, which is independent from the stress effects on baseline immune measures. Type 1 T-helper (Th)1 and proinflammatory cytokines are major activators of Th1-dependent cellular immunity, […]

Page 1 of 212