breast cancer

Raloxifene and Two New Selective Estrogen Receptor Modulators (SERMs) Inducing M2-Macrophage Shift and High IL-10 and IL-1Ra Production

Raloxifene and Two New Selective Estrogen Receptor Modulators (SERMs) Inducing M2-Macrophage Shift and High IL-10 and IL-1Ra Production

A new study published in the journal Inflammation indicates that in myeloid cells raloxifene and two new selective estrogen receptor modulators (SERMs) are able to induce a shift to M2-macrophage anti-inflammatory phenotype, characterized by high production of interleukin (IL)-10 and IL-1 receptor antagonist (IL-1Ra). Estrogens exert pleiotropic immuno-modulatory and immuno-regulatory effects, contributing to the sexual […]

Breast cancer survivors consider stress as major factor for their disease

Breast cancer survivors consider stress as major factor for their disease

According to a report and survey published in Psychooncology a substantial part of women who had survived breast cancer believe that there is a link between breast cancer and psychological stress. In this report, Stewart DE et al., from the University Health Network Women’s Health Program, University of Toronto, Canada surveyed 378 women breast cancer […]

First Evidence That Psychological Stress Alters Levels Of Suppressor Cells in Breast Cancer

First Evidence That Psychological Stress Alters Levels Of Suppressor Cells in Breast Cancer

A new study in Cellular Immunology is perhaps the first to specifically measure levels of myeloid-derived suppressor cells (MDSC) in post operative breast cancer patients who were considered to be macroscopically disease-free. In this study, Bethany Mundy-Bosse and colleagues from the Department of Integrated Biomedical Sciences, the Ohio State University, Columbus OH investigated the association […]

Biobehavioral Factors, Stress and Cancer Progression: A Contemporary Review

Biobehavioral Factors, Stress and Cancer Progression: A Contemporary Review

In two recent reviews, published in 2011, Erin Costanzo, Anil Sood and Susan Lutgendorf provide a contemporary overview of the major pathways involved in the cross-talk between behavioral factors and the immune system that contribute to cancer development¬† and progression. The idea that psychological factors may contribute to cancer development and progression is not new. […]

Celebrities, Stress and Cancer

Celebrities, Stress and Cancer

SHORT FEATURES and FACES ARTICLE Recently, several websites have reported that Michael Douglas has been diagnosed with throat cancer. The actor believes a combination of his previous hard-driving lifestyle and the stresses of the past 12 months may have caused the cancer. He tells UK’s Daily Mirror that stress was a major factor: “This type […]

The Sympathetic Nervous System as a Regulator of Breast Cancer Metastasis

The Sympathetic Nervous System as a Regulator of Breast Cancer Metastasis

A study published in the journal Cancer Research identifies sympathetic nervous system (SNS) activation as a novel physiologic regulator of breast cancer metastasis to distant tissue sites. The effects of the neuroendocrine system and microenvironment on breast cancer metastasis remain largely unexplored. Sympathetic nervous system nerve fibers are present in organs that serve as key […]