brain immune system connection

The Discovery of the Brain Lymphatic System

The Discovery of the Brain Lymphatic System

Commentary on the study by Antoine Louveau et al., Nature, 2015, 523:337-41 Structural and functional features of central nervous system lymphatic vessels Until recently, the concept that the brain is an ‘immune privileged’ organ was widely accepted. This concept was built from two main morphological concepts, 1) the impenetrability of the blood brain barrier (BBB) […]

Innervation of the Human Thymus and Spleen – an Overview

Innervation of the Human Thymus and Spleen – an Overview

Overview article The immune and nervous systems are anatomically and functionally interconnected, this cross-talk is evidenced by the dense innervation – mainly sympathetic – of the primary (bone marrow and thymus) and secondary (spleen and lymph nodes) lymphoid organs [1, 2]. Primary and secondary lymphoid organs are innervated by the autonomic nervous system resulting in […]

Tachykinins, Bone Marrow and Hematopoiesis

Tachykinins, Bone Marrow and Hematopoiesis

Overview article Hematopoiesis is the development of immune and other blood cells from a small population of stem cells known as hematopoietic stem cells (HSCs). In the embryo, hematopoiesis takes place within the yolk sac, in special tissue called blood islands [1]. Later in development, the spleen, liver, and lymphoid tissues take over this responsibility. […]