brain development

The Th17–IL-17–IL-17R System Linked To Altered Brain Development and Autism-Like Symptoms in Mice

The Th17–IL-17–IL-17R System Linked To Altered Brain Development and Autism-Like Symptoms in Mice

A new report published in Science indicates that the key pro-inflammatory cytokine interleukin (IL)-17a may interfere with the normal brain development in a mouse model of autism, causing disorganized cortical cytoarchitecture and autism-like symptoms. IL-17 is a highly pathogenic pro-inflammatory cytokine, considered a major player in several autoimmune/inflammatory diseases, whereas altered cytokine profiles and increased […]

The Link between a Curvy Body, Newborns’ Brains and Breastfeeding: or Why Do Women Need Fat?

The Link between a Curvy Body, Newborns’ Brains and Breastfeeding: or Why Do Women Need Fat?

According to two recent reports in The Sunday Times and Daily Mail there is a good reason, from a human evolutionary perspective, why women may need fat and their curvy bodies. In line with the work of Will Lassek, and his research team from the University of Pittsburgh, Pennsylvania, discussed in these reports, the ‘fat […]

Ucp2 Induction by Natural Birth and Hippocampus Development

Ucp2 Induction by Natural Birth and Hippocampus Development

A recent report published in the August issue of PLoS One indicates that natural (vaginal) birth but not Caesarian section birth in mice triggers uncoupling protein 2 (Ucp2) expression in hippocampal neurons. Mitochondrial Ucp2 is a critical determinant of fatty acid utilization by adult neurons and is involved in cell proliferation, neuroprotection and synaptogenesis in […]