New Evidence that Stress Mediators Directly Affect Hematopoiesis and Increase Neutrophil and Monocyte Production
A study published in Nature Medicine suggests that stress mediators may also directly activate hematopoietic stem cells (HSCs), which increase proliferation and differentiate into downstream progenitor cells, with the end result of an accelerated neutrophil and monocyte production. Acute stress is known to induce a transient leukocytosis, mostly due to an increase in natural killer […]
Accumulation of Myeloid-Derived Suppressor Cells: A New Mechanism in Favor of Stress-Induced Immunosuppression?
Jianfeng Jin et al. present a mechanism for the immunosuppressive potential of chronic stress in the September 2013 issue of PLoS One. The authors focus on myeloid-derived suppressor cells (MDSCs), which have been implicated in regulation of the innate and adaptive immune responses. In tumor microenvironments, MDSC expansion is stimulated by prostaglandin E2 (PGE2) and […]
Overview article Hematopoiesis is the development of immune and other blood cells from a small population of stem cells known as hematopoietic stem cells (HSCs). In the embryo, hematopoiesis takes place within the yolk sac, in special tissue called blood islands . Later in development, the spleen, liver, and lymphoid tissues take over this responsibility. […]