bone marrow

New Evidence that Stress Mediators Directly Affect Hematopoiesis and Increase Neutrophil and Monocyte Production

New Evidence that Stress Mediators Directly Affect Hematopoiesis and Increase Neutrophil and Monocyte Production

A study published in Nature Medicine suggests that stress mediators may also directly activate hematopoi¬≠etic stem cells (HSCs), which increase proliferation and differentiate into downstream progenitor cells, with the end result of an accelerated neutrophil and monocyte production. Acute stress is known to induce a transient leukocytosis, mostly due to an increase in natural killer […]

Accumulation of Myeloid-Derived Suppressor Cells: A New Mechanism in Favor of Stress-Induced Immunosuppression?

Accumulation of Myeloid-Derived Suppressor Cells: A New Mechanism in Favor of Stress-Induced Immunosuppression?

Jianfeng Jin et al. present a mechanism for the immunosuppressive potential of chronic stress in the September 2013 issue of PLoS One. The authors focus on myeloid-derived suppressor cells (MDSCs), which have been implicated in regulation of the innate and adaptive immune responses. In tumor microenvironments, MDSC expansion is stimulated by prostaglandin E2 (PGE2) and […]

Tachykinins, Bone Marrow and Hematopoiesis

Tachykinins, Bone Marrow and Hematopoiesis

Overview article Hematopoiesis is the development of immune and other blood cells from a small population of stem cells known as hematopoietic stem cells (HSCs). In the embryo, hematopoiesis takes place within the yolk sac, in special tissue called blood islands [1]. Later in development, the spleen, liver, and lymphoid tissues take over this responsibility. […]