autoimmunity and viruses

Novel TRAIL+ NK Cell Subset May Restrain Autoreactivity in Viral Infections: Implications For Sjogren’s Disease and Virus-Induced Autoimmunity

Novel TRAIL+ NK Cell Subset May Restrain Autoreactivity in Viral Infections: Implications For Sjogren’s Disease and Virus-Induced Autoimmunity

A new study published in the journal Immunity reveals a new role of TRAIL-expressing NK cells during chronic viral infection that may provide further insights into the link between viruses and autoimmune disease development. The TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) is known to induce apoptosis and selective toxicity for cancer cells. However, TRAIL also inhibits autoimmune […]

An Enterovirus Attacking the Thymus May Play a Key Role in Triggering Type 1 Diabetes

An Enterovirus Attacking the Thymus May Play a Key Role in Triggering Type 1 Diabetes

As part of the European FP6 Eurothymaide project, and, in close collaboration with Lille’s CHRU hospital (Didier Hober), the Centre d’Immunologie de Marseille-Luminy (Philippe Naquet) and the University of Tunis, Vincent Geenen and his team have discovered that infection of the thymus by the diabetogenic CV-B4 virus leads to a decrease in the transcription of […]