autism

New Function of Microglia: Promotion of Filopodia and Hence Synaptogenesis during Early Brain Development

New Function of Microglia: Promotion of Filopodia and Hence Synaptogenesis during Early Brain Development

A recent study published in Nature Communications reveals that the brain microglia influences the developing brain through induction of filopodia creation, thus, shaping neuronal connectivity and synapses formation. Microglia are important components of the neuro-immune interactions in the brain. As the resident macrophage cells, the microglial cells provide the main immune defense in the central […]

The Th17–IL-17–IL-17R System Linked To Altered Brain Development and Autism-Like Symptoms in Mice

The Th17–IL-17–IL-17R System Linked To Altered Brain Development and Autism-Like Symptoms in Mice

A new report published in Science indicates that the key pro-inflammatory cytokine interleukin (IL)-17a may interfere with the normal brain development in a mouse model of autism, causing disorganized cortical cytoarchitecture and autism-like symptoms. IL-17 is a highly pathogenic pro-inflammatory cytokine, considered a major player in several autoimmune/inflammatory diseases, whereas altered cytokine profiles and increased […]

High Neonatal Monocyte Chemotactic Protein-1 (MCP-1) Levels May Represent an Early Marker of Autism

High Neonatal Monocyte Chemotactic Protein-1 (MCP-1) Levels May Represent an Early Marker of Autism

A study published in the Journal of Neuroinflammation indicates that the chemokine monocyte chemotactic protein-1 (MCP-1) may represent an early marker for ASD. Immune dysregulation and markers of inflammation have been associated with Autism Spectrum Disorder (ASD). Yet, most of the prior studies have used specimens taken after clinical diagnosis, and even with the relatively […]

The Combination of Cortisol Diurnal Variation, IL-6 and TNF-α as Potential Diagnostic Marker in Autism

The Combination of Cortisol Diurnal Variation, IL-6 and TNF-α as Potential Diagnostic Marker in Autism

A study published in the Research in Autism Spectrum Disorders Journal indicates that cortisol, IL-6 and TNF-α may become useful markers for autism spectrum disorder (ASD). At present, 1 in 68 children in the US, and 1 in 100, in the UK, develop ASD. This is approximately a 30% increase versus the previous estimates reported […]

New Study Associates Autism Disorder Increase with Human Fetal DNA and Retroviral Contaminants in Childhood Vaccines

New Study Associates Autism Disorder Increase with Human Fetal DNA and Retroviral Contaminants in Childhood Vaccines

A study published in the September issue of the Journal of Public Health and Epidemiology is perhaps the first to examine the relationship between vaccines manufactured from human fetal cell lines and autism. In this study, Theresa Deisher and colleagues from the Sound Choice Pharmaceutical Institute (SCPI) Seattle, WA, USA identify a correlation between the […]

Oxytocin & vasopressin and human emotional and behavioral systems

Oxytocin & vasopressin and human emotional and behavioral systems

A study, published on June 12, 2012, in PLoS One, provides perhaps the first evidence that oxytocin and arginine vasopressin are both dysregulated in Williams Syndrome. Human emotion and social behavior are linked to neuroendocrine function, and two hypothalamic neuropeptides, oxytocin (OT) and arginine vasopressin (AVP) appear to regulate reproduction, social behaviors and emotionality in […]

Immune & Cytokine Dysregulation Associated With Behavioral Deficits In A Mouse Model Of Autism

Immune & Cytokine Dysregulation Associated With Behavioral Deficits In A Mouse Model Of Autism

A new report in the Proceedings of the National Academy of Sciences of the USA (PNAS) indicates that cellular and cytokine immune dysregulation may contribute to the autism spectrum disorder (ASD)-related behavioral deficits in a mouse model of an autism. Recent evidence indicates the involvement of an abnormal immune system activity in the pathogenesis of […]

Cytokine Profiles in Subjects with Autism Spectrum Disorders

Cytokine Profiles in Subjects with Autism Spectrum Disorders

In a study published in the online journal PLoS ONE, a research group from the Hamamatsu University School of Medicine, Hamamatsu, Japan reports the presence of high levels of several pro-inflammatory cytokines in male (≥6 years old) subjects with autism spectrum disorder (ASD). ASD include autistic disorder, Asperger’s disorder and pervasive developmental disorder. A dysregulation […]

High Levels of IFN-Gamma, IL-4 and IL-5 in Mothers Bearing Autistic Children

High Levels of IFN-Gamma, IL-4 and IL-5 in Mothers Bearing Autistic Children

A study by Paula E Goines et al., published in Molecular Autism, indicates that divergent cytokine profiles are expressed in serum samples taken during the second trimester of pregnancy from i) mothers bearing a child with autism spectrum disorder (ASD); ii) a child with a developmental delay (DD) other than ASD; or iii) a child from the […]