atherosclerosis

Increased Risk of Heart Attack Linked To Polymorphism in the 5HTR2C Serotonin Receptor Gene

Increased Risk of Heart Attack Linked To Polymorphism in the 5HTR2C Serotonin Receptor Gene

In the December 2013 issue of PLOS One, a research team from the Department of Psychiatry, Duke University Medical Center, Durham, NC reports that a functional polymorphism of the 5HTR2C gene is associated with a 38% increased risk for cardiovascular disease events. This includes mortality and myocardial infarction (MI), independent of several traditional risk factors, […]

Psychological Distress Is Dose-Dependently Related to Increased Mortality

Psychological Distress Is Dose-Dependently Related to Increased Mortality

A recent study published in the 2012 July issue of the British Medical Journal is probably the largest so far to show that a dose-response association exists between psychological distress and major causes of mortality across the full range of distress. Psychological stress has been linked to the development and progression of several common human […]

Interleukin-6 – a Better Predictor of Future Cardiovascular Events Than C-Reactive Protein?

Interleukin-6 – a Better Predictor of Future Cardiovascular Events Than C-Reactive Protein?

In a study published in the journal Cytokine, Hidenori Nishida and colleagues from the National Cerebral and Cardiovascular Center, Suita, Japan, demonstrate that an increased level of serum IL-6 is a significant predictor of future cardiovascular (CV) events in high-risk Japanese patients, independently of a variety of influencing factors. One of the paradigm shifts in […]

Elevated Plasma IL-10 Levels are a Strong Predictor of Long-Term Adverse Outcomes in Acute Coronary Syndrome

Elevated Plasma IL-10 Levels are a Strong Predictor of Long-Term Adverse Outcomes in Acute Coronary Syndrome

Interleukin (IL)-10 is often considered as a ‘cardioprotective’ cytokine, but a recent study published in the American Journal of Medicine reports an ‘unexpected’ observation that elevated baseline plasma levels of IL-10 are a strong predictor of long-term adverse cardiovascular outcomes in patients with acute coronary syndrome. Interleukin-10 is an immunoregulatory cytokine with strong anti-inflammatory properties. […]

Stress, Immunity and Coronary Artery Disease

Stress, Immunity and Coronary Artery Disease

In this review Roger Ho and colleagues discuss how stress hormones through affecting different components of the immune/inflammatory reaction may in turn contribute to the development of coronary artery disease (CAD). Recent evidence indicates that acute and chronic psychological stress, such as intense anger, low socioeconomic status, work stress, social isolation, depression, anxiety and hostility […]