asthma

IL-27 and IFN-Gamma Cooperate to Induce Steroid Resistance in Asthma

IL-27 and IFN-Gamma Cooperate to Induce Steroid Resistance in Asthma

The mechanisms driving steroid resistance in asthma are poorly understood, but a new study published in Journal of Immunology indicates that a novel interleukin (IL)-27– and interferon (IFN)-γ–driven pathway may contribute to this process, where the activation of MyD88-dependent pathways in macrophages may play a critical role. The major downstream molecules that regulate IFN-gamma and […]

Andor Szentivanyi and the Beta Adrenergic Theory of Allergy and Asthma

Andor Szentivanyi and the Beta Adrenergic Theory of Allergy and Asthma

Historical Perspectives Fifty six years ago Andor Szentivanyi and colleagues were the first to document with exact scientific methodology in animal experiments that the nervous system regulates anaphylactic reactions and antibody production. At that time Szentivanyi was a resident at the Medical School of Debrecen in Hungary. He observed that adrenaline did not inhibit the […]

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