A Sympathetic-Adrenal Neuroimmune Reflex Linked to the Immunosuppressive Effects of Spinal Cord Injury
A recent study published in Nature Neuroscience indicates that the increased susceptibility to life-threatening infections in spinal cord injury (SCI) patients may result from the disruption of the physiological interactions within a neuroendocrine reflex involving the sympathetic nervous system (SNS) and the adrenal glands.
The control of the immune system by the peripheral autonomic nervous system is well known. This control shapes immunity through different neuro-immune interfaces where neurons communicates with peripheral organs, as the spleen and adrenal glands, regulating the release of neurohormones or stimulating neuronal pathways innervating the target organ. In these interactions, the spinal cord serves as a neural conduit for the neuroimmune signal trafficking between the central nervous system and peripheral immunomodulatory organs.
Patients with spinal cord injury conditions are known to have increased occurrence of infections due to secondary neurally-induced immunosuppression. The current view regards this immunosuppression as the result of SNS noradrenergic overactivation and the excessive release of glucocorticoids due to a dysregulated hypothalamus–pituitary–adrenal (HPA) axis. However, it is unknown whether these changes are due to humoral, via corticosteroids, or neural, via the SNS disruptions.
In the study published on Nature Neuroscience, Harald Prüss and colleagues from the Department of microbiology and immunobiology, Harvard medical school, Boston, Massachusetts showed that high level (Th1) thoracic spinal cord transection decreased peripheral norepinephrine (noradrenaline) levels and increased corticosterone levels in mice without activating the HPA axis. In these animals, severe leukopenia, lymphoid organs atrophy, and spontaneous pneumonia developed. Moreover, SCI impaired thymic (T lymphocyte) and bone marrow (B lymphocyte) cell maturation and induced leukocyte apoptosis.
These post-SCI effects were inhibited by proper manipulation of the humoral or neural pathways. Adrenalectomy (ADX) or adrenal denervation (ANX) restored T and B-cell maturation and blood leukocyte count. Notably, ADX prevented lymphoid organ atrophy, and ANX animals did not develop pneumonia.
Thus, according to the authors, the “susceptibility to spontaneous pneumonia and severe lymphopenia after SCI resulted from a maladaptive sympathetic-neuroendocrine reflex involving the adrenal glands”. Importantly, they discuss that the sympathetic deafferentation of the adrenal gland contributed to the depletion of NE release from the adrenal medulla and the disinhibition of glucocorticoid release from the adrenal cortex, indicating a primary (i.e., adrenal) hypercortisolism.
The authors propose a two-step reflex mechanism where disruption of the tonic control of the adrenal glands by spinal cord efferents is followed by systemic effects that include low catecholamine levels and increased glucocorticoid release. These mechanisms have a major impact on lymphocyte maturation and migration, lymphoid organ development and cardiovascular alterations that may explain the immunosuppressive effects observed after SCI.
Source: Nature Neuroscience, 2017. September 18. doi: 10.1038/nn.4643
Read more: Nature Neuroscience
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