News

A mix of news reporting on the latest developments in neuroendocrine-immunology & stress-immunity research

The TRPV1 Pain Receptor is Expressed and Functionally Active in Human T Lymphocytes

The TRPV1 Pain Receptor is Expressed and Functionally Active in Human T Lymphocytes

A study published in Nature Immunology reveals a previously unrecognized, ‘non-canonical’ role of the pain TRPV1 receptor – namely, its functional expression, and involvement in TCR signaling and pro-inflammatory activities of T cells. Transient receptor potential vanilloid type 1 ion channel (TRPV1), initially identified as the receptor for capsaicin (the hot ingredient of chilli peppers) […]

New Evidence that Stress Mediators Directly Affect Hematopoiesis and Increase Neutrophil and Monocyte Production

New Evidence that Stress Mediators Directly Affect Hematopoiesis and Increase Neutrophil and Monocyte Production

A study published in Nature Medicine suggests that stress mediators may also directly activate hematopoi­etic stem cells (HSCs), which increase proliferation and differentiate into downstream progenitor cells, with the end result of an accelerated neutrophil and monocyte production. Acute stress is known to induce a transient leukocytosis, mostly due to an increase in natural killer […]

Chronic Stress and IL-10/STAT3 Pathway’s Induction

Chronic Stress and IL-10/STAT3 Pathway’s Induction

A study published in Brain, Behavior, and Immunity journal indicates that the interleukin (IL)-10/STAT3 pathway may play a key role in the immunosuppression induced by chronic stress. IL-10 is a major anti-inflammatory cytokine, which possesses potent immunosuppressive actions. Stress mediators, particularly catecholamines (CAs), are potent IL-10 inducers, and in clinical conditions such as brain trauma, […]

Magnified Peripheral IL-6 Response Linked To Stress Susceptibility and Higher Risk of Depression

Magnified Peripheral IL-6 Response Linked To Stress Susceptibility and Higher Risk of Depression

A new study published in the Proceedings of the National Academy of Sciences of the USA is perhaps the first to demonstrate that the magnitude of peripheral interleukin (IL)-6 responses preceding stress challenge may confer inter-individual differences in susceptibility or resilience to a subsequent social stressor. Previous research indicates that in humans both major depression […]

New Evidence That Stress In Pregnancy Increases Susceptibility to Asthma In Offspring

New Evidence That Stress In Pregnancy Increases Susceptibility to Asthma In Offspring

A recent study published in the American Journal of Physiology – Lung Cellular and Molecular Physiology indicates that release of glucocorticoids (GCs) as the result of stress during pregnancy can induce asthma susceptibility in offspring. It is known that psychological stress contributes to the pathogenesis and exacerbations of asthma. One mechanism may be the capacity […]

Hyperactive Type I Interferon System in the Choroid Plexus Linked To Aging and Cognitive Dysfunction

Hyperactive Type I Interferon System in the Choroid Plexus Linked To Aging and Cognitive Dysfunction

A study published in the August 21, 2014 issue of Science magazine demonstrates that aging is associated with an overactive interferon (IFN)-I system at a specific brain structure, the choroid plexus. This vascular tissue, found in all cerebral ventricles, is an epithelial monolayer that forms the blood-cerebrospinal fluid barrier, and, in fact, represents the ‘interface’ […]

Sympathetic Neuropathy Linked To the Development of Myeloproliferative Neoplasms

Sympathetic Neuropathy Linked To the Development of Myeloproliferative Neoplasms

A new study published in the August 07, 2014 issue of Nature magazine reveals that an impaired neuro-endocrine microenvironment of the bone marrow plays a crucial role in the development and clinical outcome of myeloproliferative neoplasms (MPNs). This and related studies may represent a breakthrough in hematology research and a paradigm shift in the MPNs’ […]

First Evidence of Sensory Nerves Driving Interleukin-23 Production in Skin: A Breakthrough in Psoriasis Research?

First Evidence of Sensory Nerves Driving Interleukin-23 Production in Skin: A Breakthrough in Psoriasis Research?

A study published in the June 05, 2014 issue of Nature magazine indicates that sensory nerve-driven interleukin-(IL)-23 production by dermal dendritic cells (DDCs) contributes to psoriasis-like inflammation. These findings may represent a breakthrough in psoriasis research and the understanding of the pathogenesis of this skin disease. The IL-23→IL-17 axis plays a major role in the […]

Large Population Study Links Stress in Middle Age Women to Dementia and Alzheimer’s Risk Decades Later

Large Population Study Links Stress in Middle Age Women to Dementia and Alzheimer’s Risk Decades Later

A Swedish study, published in the August 2013 online issue of BMJ Open indicates that a higher number of psychosocial stressors in middle-aged women were associated with increased risk of dementia and Alzheimer’s disease (AD) decades later in life. This is perhaps the first population study on the relationship between midlife stressors and increased risk […]

New Animal Stress Model Links the Stress-Induced T-helper 2 Shift to Colon Cancer Growth

New Animal Stress Model Links the Stress-Induced T-helper 2 Shift to Colon Cancer Growth

In the October 2013 issue of Biochemical and Biophysical Research Communications, Ni Hou and colleagues from the Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi, China, demonstrated that a novel form of sound stress induced a T helper (Th)2 shift and that this is related to colon cancer progression in mice. Numerous epidemiological reports indicate […]