News

A mix of news reporting on the latest developments in neuroendocrine-immunology & stress-immunity research

Evidence that Napping May Correct Interleukin-6 Changes and the Stress Induction Caused By Sleep Deprivation

Evidence that Napping May Correct Interleukin-6 Changes and the Stress Induction Caused By Sleep Deprivation

A study published in the March issue of The Journal of Clinical Endocrinology & Metabolism (JCEM) indicates that short-term napping is able to restore, to a great extent, the neurohormonal and immune changes induced by sleep deprivation. Insufficient sleep is well-known to be associated with poor attention and performance deficits. However, an increasing body of […]

Blood Levels of the New Anti-Inflammatory Cytokine IL-37 Are Increased In Rheumatoid Arthritis Patients

Blood Levels of the New Anti-Inflammatory Cytokine IL-37 Are Increased In Rheumatoid Arthritis Patients

A recent study published in PLoS One suggests that interleukin (IL)-17 is involved in a control circuit that tries to regulate inflammation in rheumatoid arthritis. Rheumatoid arthritis (RA) is associated with increased levels of pro-inflammatory cytokines such as IL-6, IL-17A and tumor necrosis factor (TNF)-α. Early intervention and treatment of RA is based on disease-modifying […]

TRPV1 Sensory Nerves May Be Key to the Genesis of Airway Hyperreactivity in Experimental Asthma

TRPV1 Sensory Nerves May Be Key to the Genesis of Airway Hyperreactivity in Experimental Asthma

A new study in the Proceedings of the National Academy of Sciences (PNAS) of the USA implicates the transient receptor potential vanilloid 1 (TRPV1)-expressing sensory nerves in the pathogenesis of asthma and/or asthma attacks. The TRPV1 receptor, initially identified as the receptor for capsaicin, the hot component of chilli peppers, is typically expressed in sensory […]

Blocking IL-12 and IL-23 in APPPS1 Mouse Model Shows Promise as an Experimental Therapeutic Approach to Alzheimer’s Disease

Blocking IL-12 and IL-23 in APPPS1 Mouse Model Shows Promise as an Experimental Therapeutic Approach to Alzheimer’s Disease

A recent study, published in Nature Medicine is perhaps the first one to show interleukin (IL)-23 involvement, and implicates both IL-23 and IL-12, key pro-inflammatory cytokines in the pathogenesis of Alzheimer’s disease. Importantly, it also demonstrates that in the APPPS1 Alzheimer’s disease mouse model, preventing the effects of these mediators, or ‘immune hormones’, with antibodies […]

Further Evidence That Prenatal Exposure to Stress May Increase the Risk of Asthma Development in Later Life

Further Evidence That Prenatal Exposure to Stress May Increase the Risk of Asthma Development in Later Life

A recent study published in the BioMed Research International journal suggests that maternal stress during pregnancy is able to increase offspring risk and susceptibility to asthma. Previous research indicates that prenatal and early-life stress can modify infant immune function in the long-term, including conferring a higher risk for childhood asthma (MK Pincus-Knackstedt et al., 2006; […]

New Evidence Indicates that Oxytocin Deficiency May Represent a Biomarker of Anxiety in Children

New Evidence Indicates that Oxytocin Deficiency May Represent a Biomarker of Anxiety in Children

A study by Karen Parker and her research team from the Stanford University School of Medicine links low levels of oxytocin with anxiety in children. Recent evidence indicates that oxytocin is an anxiolytic hormone, as it decreases the release of stress hormones, while oxytocin imbalances have been associated with both anxiety (HJ Lee et al., […]

Vagus Nerve Stimulation Ameliorates Disease Activity in a Rodent Model of Rheumatoid Arthritis

Vagus Nerve Stimulation Ameliorates Disease Activity in a Rodent Model of Rheumatoid Arthritis

A study published in PLoS ONE is perhaps the first to demonstrate that electrical neurostimulation of the vagus nerve reduces signs of inflammation and disease severity in the collagen-induced arthritis (CIA), a disease model of rheumatoid arthritis in rodents. Previous research indicates that cholinergic signaling along the vagus nerve is able to affect the production […]

High Neonatal Monocyte Chemotactic Protein-1 (MCP-1) Levels May Represent an Early Marker of Autism

High Neonatal Monocyte Chemotactic Protein-1 (MCP-1) Levels May Represent an Early Marker of Autism

A study published in the Journal of Neuroinflammation indicates that the chemokine monocyte chemotactic protein-1 (MCP-1) may represent an early marker for ASD. Immune dysregulation and markers of inflammation have been associated with Autism Spectrum Disorder (ASD). Yet, most of the prior studies have used specimens taken after clinical diagnosis, and even with the relatively […]

The Combination of Cortisol Diurnal Variation, IL-6 and TNF-α as Potential Diagnostic Marker in Autism

The Combination of Cortisol Diurnal Variation, IL-6 and TNF-α as Potential Diagnostic Marker in Autism

A study published in the Research in Autism Spectrum Disorders Journal indicates that cortisol, IL-6 and TNF-α may become useful markers for autism spectrum disorder (ASD). At present, 1 in 68 children in the US, and 1 in 100, in the UK, develop ASD. This is approximately a 30% increase versus the previous estimates reported […]

Deficit of Oxytocin in Women with Major Depression

Deficit of Oxytocin in Women with Major Depression

A new study published in the Journal of Psychiatric Research extends the results of two previous studies and provides evidence that oxytocin levels are low in women with depression, including patients with psychotic major depression (PMD), who typically exhibit greater depressive severity. The neuropeptide oxytocin has been implicated in many aspects of reproductive and social […]