News

A mix of news reporting on the latest developments in neuroendocrine-immunology & stress-immunity research

New Evidence That Psychological Stress Contributes To Peptic Ulcers Development

New Evidence That Psychological Stress Contributes To Peptic Ulcers Development

A new study published in the journal Clinical Gastroenterology and Hepatology provides new evidence that stress is related to an increased risk of peptic ulcers. Since the pioneering work of Hans Selye in the 1930s, psychological stress was often linked to the induction and progression of peptic ulcers. In the 1950s-60s, Selye began to promote […]

The Association of Body Composition and Novel Bioimpedance Measurements with Chronic Stress and Inflammation Biomarkers

The Association of Body Composition and Novel Bioimpedance Measurements with Chronic Stress and Inflammation Biomarkers

A recent study by Constantine Tsigos et al., published in the European Journal of Clinical Investigation (EJCI) indicates that the presence of ‘medically unexplainable symptoms’ (MUS) is an index of chronic stress and inflammation, and that advanced bioimpedance analysis may provide a useful, bloodless and rapid tool in the clinical setting. Chronic stress plays two […]

Vasoactive Intestinal Peptide Inhibits Pathogenic Th17 Cells from Rheumatoid Arthritis Patients

Vasoactive Intestinal Peptide Inhibits Pathogenic Th17 Cells from Rheumatoid Arthritis Patients

A study published in the Journal of Leukocyte Biology indicates that in blood from rheumatoid arthritis (RA) patients, vasoactive intestinal peptide (VIP) shifts the activity of T cells towards a more T regulatory cell phenotype, and reduces the pathogenic profile of T helper (Th)17 cells. The vasoactive intestinal peptide (VIP) is well-known for its immunoregulatory […]

Evidence for Small Fiber Neuropathy in the Cornea of Fibromyalgia Patients

Evidence for Small Fiber Neuropathy in the Cornea of Fibromyalgia Patients

A new study published in Seminars in Arthritis & Rheumatism indicates that in patients with fibromyalgia the density of small nerve fibers in the cornea is reduced, supporting an evolving concept that fibromyalgia is a small fiber neuropathy. Fibromyalgia is also considered a stress-related syndrome that affects predominantly women. Recent research suggests that fibromyalgia is […]

Cytokines Driving Sympathetic Nervous System Activation in the Subfornical Organ: Implications for Heart Failure and Hypertension

Cytokines Driving Sympathetic Nervous System Activation in the Subfornical Organ: Implications for Heart Failure and Hypertension

A recent study published in Hypertension demonstrates that cytokines such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α acting at the level of the subfornical organ induce the expression of inflammatory and excitatory mediators that subsequently drive sympathetic nervous system activation. The subfornical organ (SFO), a highly vascularized structure is a circumventricular organ that lacks […]

Vitamin D Deficiency May Contribute to the Reduction of Sympathetic and Sensory Innervation in Arthritis

Vitamin D Deficiency May Contribute to the Reduction of Sympathetic and Sensory Innervation in Arthritis

A new study published in Neuroscience demonstrates that vitamin D deficiency in experimental animals is related to sensory and sympathetic denervation and reduced neurotrophin levels in the synovium. Several studies have associated vitamin D levels with rheumatoid arthritis (RA) development in humans. Thus, low vitamin D levels are documented in patients with active RA. Also […]

Stress-Induced β2-Adrenoceptor-Mediated M2 Macrophage Polarization Promoting Tumor Growth in a Mouse Model of Breast Cancer

Stress-Induced β2-Adrenoceptor-Mediated M2 Macrophage Polarization Promoting Tumor Growth in a Mouse Model of Breast Cancer

A new study published in the BMB Reports indicates that stress hormones such as epinephrine (adrenaline) may promote the transformation of M1-type macrophages to M2-type macrophages and, thus, accelerate tumor growth in a mouse model of breast cancer. Several studies have linked psychological stress and breast cancer risk, associating with the involvement of stress mediators […]

High Blood Interferon-γ Levels Linked to the Early Phase of Chronic Fatigue Syndrome

High Blood Interferon-γ Levels Linked to the Early Phase of Chronic Fatigue Syndrome

A study published in the February issue of the new journal Science Advances is perhaps the first to identify distinct stages of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Importantly, it demonstrates some immune signatures early in the course of ME/CFS that are not present in subjects with longer duration of illness. Although efforts were made to […]

Glucocorticoid Resistance of Th17 Cells in Takayasu Arteritis

Glucocorticoid Resistance of Th17 Cells in Takayasu Arteritis

A study published in the Arthritis & Rheumatology journal is perhaps the first to demonstrate that T helper (Th)1 and Th17 cells and cytokine pathways may play central role in driving systemic inflammation in Takayasu arteritis. Takayasu arteritis (TA) is a rare type of vasculitis that affects mostly middle-aged women, with greater frequency in Asia, […]

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptor Agonists in a Murine Model of Rheumatoid Arthritis

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptor Agonists in a Murine Model of Rheumatoid Arthritis

According to van Maanen et al., and their recent publication in PLoS One, two new experimental compounds affecting the acetylcholine-receptor system are able to delay collagen-induced arthritis (CIA) in mice, showing the therapeutic potential of chemicals targeting the α7 subunit of nicotinic acetylcholine receptors (α7nAChR). Previous research revealed that the efferent vagus nerve may decrease […]