News

A mix of news reporting on the latest developments in neuroendocrine-immunology & stress-immunity research

Stress and Catecholamines Up-Regulate Proinflammatory Cytokine Production and Neutrophil Infiltration in Experimental Colitis

Stress and Catecholamines Up-Regulate Proinflammatory Cytokine Production and Neutrophil Infiltration in Experimental Colitis

A recent Brain, Behavior and Immunity study indicates that psychological stress contributes to the exacerbation of the murine model of colitis by promoting the mobilization and entry of neutrophils in the colon. This appears to be achieved by the up-regulation of pro-inflammatory cytokine and chemokine production and STAT3 signaling, and involves β1/β2-adrenergic receptors activation. Inflammatory […]

Glucocorticoid-Resistant IL-17- and IL-22-secreting CD4+ T Cells May Contribute to Increased Disease Activity in Multiple Sclerosis

Glucocorticoid-Resistant IL-17- and IL-22-secreting CD4+ T Cells May Contribute to Increased Disease Activity in Multiple Sclerosis

A recent study published in Immunology is perhaps the first to demonstrate a correlation between the production of interleukin (IL)-17 and IL-22, and its glucocorticoid resistance, and the number of active brain lesions in multiple sclerosis (MS). Increased active brain lesions were found in patients whose IL-17- and IL-22-producing T cells were more resistant to […]

First Evidence that Meningeal Interferon-γ Affects Neuronal Connectivity and Social Behavior

First Evidence that Meningeal Interferon-γ Affects Neuronal Connectivity and Social Behavior

A recent study published in Nature magazine links the meningeal immunity to the regulation of social behavior, implicating the meningeal interferon (IFN)-γ and its modulatory effects on the activity of brain cortex GABAergic neurons. Diseases such as autism spectrum disorder, frontotemporal dementia and schizophrenia are characterized by severe social and immune dysfunction. Little is known […]

Chronic Stress Induces Shrinkage of Medial Amygdala Neurons in Mice: Recovery by the Fast-Acting Candidate Antidepressant Acetyl-L-Carnitine

Chronic Stress Induces Shrinkage of Medial Amygdala Neurons in Mice: Recovery by the Fast-Acting Candidate Antidepressant Acetyl-L-Carnitine

A recent study in Molecular Psychiatry provides new evidence that chronic stress generates structural remodelling of the brain amygdala, and particularly the shrinkage of medial amygdala neurons in mice. Chronic stress has been linked to cognitive impairment, but it is also known that stress modifies the neuronal architecture in several brain cognitive areas. However, little […]

Deficiency of Stress Resilience in Late Adolescence Linked To Increased Risk of Hypertension in Adulthood

Deficiency of Stress Resilience in Late Adolescence Linked To Increased Risk of Hypertension in Adulthood

A new study published in the journal Heart indicates that men with low stress resilience during youth are prone to approximately 40% increase in the risk of developing hypertension in later life. Of note, the combination of low stress resilience and high body mass index (BMI) triples the hypertension risk. High blood pressure is a […]

Norepinephrine May Shift the IL-12/IL-23 Ratio of Dendritic Cells towards IL-23 Predominance thus Favoring Th17 Differentiation

Norepinephrine May Shift the IL-12/IL-23 Ratio of Dendritic Cells towards IL-23 Predominance thus Favoring Th17 Differentiation

A new study published in the January 15, 2016 issue of the Journal of Immunology indicates that in murine bone marrow–derived dendritic cells (DCs), norepinephrine, via stimulation of β2-adrenoceptors, is able to promote a shift in the IL-12p70/IL-23 cytokine ratio. Primary and secondary lymphoid organs receive a rich autonomic nervous system innervation, mainly by the […]

More Evidence that Norepinephrine and β3-Adrenoreceptors May Drive Melanoma Progression & Aggressiveness

More Evidence that Norepinephrine and β3-Adrenoreceptors May Drive Melanoma Progression & Aggressiveness

A report recently published in Oncotarget shows that the β3-adrenoreceptors are involved in melanoma aggressiveness, and that these receptors, expressed on several accessory cells, may orchestrate their function and thus, sustain melanoma progression. Recent research indicates that stress and stress mediators contribute to cancer development and/or progression. It appears that in this process a major […]

Stress May Start Driving Cardiovascular and Metabolic Risk Early In Life: Evidence from the 1958 British Birth Cohort Study

Stress May Start Driving Cardiovascular and Metabolic Risk Early In Life: Evidence from the 1958 British Birth Cohort Study

Ashley Winning et al. from the Harvard T.H. Chan School of Public Health, Boston, Massachusetts report in the the Journal of the the American College of Cardiology that psychological stress in childhood, adulthood or persistent across a person’s life can contribute to high cardiovascular and metabolic risk. Many clinical and epidemiological studies have documented the […]

New Evidence that Peripheral Nerves Sense Infection and Drive IL-23 Production by Skin Dendritic Cells

New Evidence that Peripheral Nerves Sense Infection and Drive IL-23 Production by Skin Dendritic Cells

In a new study published in the journal Immunity, Sakeen Kashem and colleagues from the University of Minnesota, Minneapolis, MN, USA report that in the murine skin, IL-23, derived from CD301b+ DCs drives IL-17A production by γδ T cells, and this cytokine network is required to establish resistance to cutaneous candidiasis. Interleukin (IL)-23 is a […]

Low Cortisol and Glucocorticoid Signaling But High Levels of Inflammation: Risk Factors for Developing Depression in Patients with Coronary Heart Diseases

Low Cortisol and Glucocorticoid Signaling But High Levels of Inflammation: Risk Factors for Developing Depression in Patients with Coronary Heart Diseases

A new Brain Behavior and Immunity study indicates that depression in coronary heart disease (CHD) is associated with high levels of inflammation in the context of low cortisol output and glucocorticoid receptor (GR) resistance. Coronary heart disease (CHD) and major depressive disorders (MDD) are among the major causes of disability in developed countries. There is […]