News

A mix of news reporting on the latest developments in neuroendocrine-immunology & stress-immunity research

Early Childhood Stress is Associated With Elevated Antibody Levels to Herpes Simplex Virus Type 1 in Adolescence

Early Childhood Stress is Associated With Elevated Antibody Levels to Herpes Simplex Virus Type 1 in Adolescence

A study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) indicates that a stressful early childhood history affects the long-term functioning of the immune system, specifically evidenced by a secretion of higher levels of herpes simplex virus (HSV)-antibodies into saliva. The link between psychological stress and […]

Regulatory T Cells are Cerebroprotective in Acute Experimental Stroke

Regulatory T Cells are Cerebroprotective in Acute Experimental Stroke

A recent Nature Medicine study by Arthur Liesz et al. indicates that regulatory T cells (Treg) are cerebroprotective after experimental brain ischemia or stroke, and that interleukin (IL)-10 appears to be the major mediator of the cerebroprotective effects. Recent evidence indicates that inflammatory mechanisms such as up-regulation of pro-inflammatory cytokines and leukocytes’ invasion in the […]

PACAP as an Intrinsic Regulator of Treg Abundance

PACAP as an Intrinsic Regulator of Treg Abundance

A study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) provides perhaps the first evidence that endogenous pituitary adenylyl cyclase-activating polypeptide (PACAP) modulates the production or expansion of regulatory T cells (Treg) and T helper (Th)17 lymphocytes. PACAP is a 38-amino-acid neuropeptide identified in 1989 from […]

Estrogens and Dendritic Cells

Estrogens and Dendritic Cells

A study published in the Journal of Immunology demonstrates that estrogens may boost innate immunity by enhancing interferon (IFN)-γ production by CD11c(+) dendritic cells. In humans, the sex differences or the sexual dimorphism in immune defense is a well-known phenomenon. Females have more vigorous cellular and humoral immune responses, and they are more resistant to […]