News

A mix of news reporting on the latest developments in neuroendocrine-immunology & stress-immunity research

Interactions Among IL-33, Substance P and Mast Cells May Contribute to the Pathogenesis of Psoriasis

Interactions Among IL-33, Substance P and Mast Cells May Contribute to the Pathogenesis of Psoriasis

A new study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) indicates that substance P (SP) stimulates human mast cells to secrete vascular endothelial growth factor (VEGF) and that this action is augmented by interleukin (IL)-33. Substance P-positive nerve fibers are denser in psoriatic lesions and […]

Priming of Murine Bone Marrow-Derived Dendritic Cells with Epinephrine Favors the Induction of a Dominant Th2/Th17 Phenotype

Priming of Murine Bone Marrow-Derived Dendritic Cells with Epinephrine Favors the Induction of a Dominant Th2/Th17 Phenotype

A new study published in the journal Brain, Behavior, and Immunity indicates that the stress hormone epinephrine (also known as adrenaline) is able to drive a Th2/Th17-shift in dendritic cells (DCs) in the presence of a pathogenic stimulus. Dendritic cells cytokine and chemokine profiles are able to shape CD4+ T cell pathways and phenotypes and […]

Epinephrine and Mobilization of Cytotoxic Leukocytes

Epinephrine and Mobilization of Cytotoxic Leukocytes

A new Journal of Immunology study suggests that during acute stress the hormone epinephrine (adrenaline) is rapidly causing demargination of cytotoxic effector leukocytes from the marginal pool of blood vessels, thus releasing these cells into the circulation, which, in turn, may provide immediate protection from invading pathogens. Acute stress in humans is known to cause […]

Substance P Promotes Th17 Phenotype in Generalized Anxiety Disorder

Substance P Promotes Th17 Phenotype in Generalized Anxiety Disorder

A study published in the journal of Clinical Immunology demonstrates that the cytokine profiles in generalized anxiety disorder (GAD) individuals show traits of Th1 and Th2 deficiencies but are associated with a predominant Th17 phenotype, particularly in the presence of substance P (SP). Substance P has been shown to stimulate the inflammatory response, contributing to […]

Overview of the ”New Generation” Cytokines

Overview of the ”New Generation” Cytokines

In this review, published in Arthritis Research & Therapy Cem Gabay and Iain McInnes present the biology and relevant pathophysiology of several novel cytokines, with focus on their involvement in rheumatic diseases. This list includes the interleukin (IL)-1 superfamily (IL-18 and IL-33), the IL-12 superfamily (IL-27 and IL-35), the IL-2 superfamily (IL-15 and IL-21), and […]

Childhood Roots of Health Disparities

Childhood Roots of Health Disparities

Recently, in the Journal of the American Medical Association (JAMA), Jack Shonkoff, W. Thomas Boyce and Bruce McEwen discussed a new way of thinking about health promotion and disease prevention. Adult conditions such as coronary heart disease, stroke, diabetes, and cancer are believed to be causally related to adult behavior and lifestyles only. But recent […]

Stress and Disorders of the Stress System

Stress and Disorders of the Stress System

A recent article published in Nature Reviews Endocrinology provides a brief but comprehensive overview on the conceptual evolution, and current understanding of homeostasis and the pathogenic disturbances that are associated with stress and the disorders of the stress system. Homeostasis, a term coined by the American physiologist Walter Cannon in the beginning of the 20th […]

Innate Immune Responses Linked to Seizures

Innate Immune Responses Linked to Seizures

A study published in the journal Brain indicates that the innate immune response to toll-like receptor 4 (TLR4) ligands, most likely involving activated microglia and release of interleukin (IL)-1, results in increased neuronal excitability sufficient to trigger experimental seizures in vivo. An increasing body of evidence suggests that inflammatory processes may play an important role […]

Growth Hormone (GH) Replacement and Thymus Function

Growth Hormone (GH) Replacement and Thymus Function

A recent PLoS One study by Gabriel Morrhaye et al., demonstrates that the functional integrity of the somatotrope growth hormone/insulin-like growth factor-1 axis is important for the maintenance of a normal thymus function in human adults. The secretion of growth hormone (GH) declines with aging until only low levels can be detected in individuals aged […]

Early Childhood Stress is Associated With Elevated Antibody Levels to Herpes Simplex Virus Type 1 in Adolescence

Early Childhood Stress is Associated With Elevated Antibody Levels to Herpes Simplex Virus Type 1 in Adolescence

A study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) indicates that a stressful early childhood history affects the long-term functioning of the immune system, specifically evidenced by a secretion of higher levels of herpes simplex virus (HSV)-antibodies into saliva. The link between psychological stress and […]