News

A mix of news reporting on the latest developments in neuroendocrine-immunology & stress-immunity research

Thyroxine – an Endogenous Inhibitor of Migration Inhibitory Factor (MIF) Proinflammatory Activity

Thyroxine – an Endogenous Inhibitor of Migration Inhibitory Factor (MIF) Proinflammatory Activity

A new study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) suggests that thyroxine (T4) is a strong endogenous inhibitor of the migration inhibitory factor (MIF) pro-inflammatory activities. Importantly, the study also indicates that low T4 and high MIF levels may contribute to the lethal systemic […]

Cytokine Profiles in Subjects with Autism Spectrum Disorders

Cytokine Profiles in Subjects with Autism Spectrum Disorders

In a study published in the online journal PLoS ONE, a research group from the Hamamatsu University School of Medicine, Hamamatsu, Japan reports the presence of high levels of several pro-inflammatory cytokines in male (≥6 years old) subjects with autism spectrum disorder (ASD). ASD include autistic disorder, Asperger’s disorder and pervasive developmental disorder. A dysregulation […]

High Levels of IFN-Gamma, IL-4 and IL-5 in Mothers Bearing Autistic Children

High Levels of IFN-Gamma, IL-4 and IL-5 in Mothers Bearing Autistic Children

A study by Paula E Goines et al., published in Molecular Autism, indicates that divergent cytokine profiles are expressed in serum samples taken during the second trimester of pregnancy from i) mothers bearing a child with autism spectrum disorder (ASD); ii) a child with a developmental delay (DD) other than ASD; or iii) a child from the […]

Neurobiology of Cancer

Neurobiology of Cancer

In a Personal View article, published in The Lancet Oncology Katarina Ondicova and Boris Mravec address a timely topic of growing interest, the role of the nervous system or the neurobiology of cancer etiopathogenesis. Circa 200 A.D. Galen, the Greek physician and philosopher was perhaps the first to link ‘cancer’ with the person’s emotional and […]

The ‘Old Friends’ Hypothesis and Why Living in the Modern World May Increase Vulnerability to Major Depression

The ‘Old Friends’ Hypothesis and Why Living in the Modern World May Increase Vulnerability to Major Depression

In this paper, Raison et al. explore evidence that the ‘old friends’ theory, heretofore associated with allergic and autoimmune diseases, can also be applied to major depression. The ‘old friends’ theory suggests that immune interactions with pseudocommensal mycobacterial species, gut flora members and helminthes regulate the immune system, thus explaining lower rates of atopic (Th2-mediated) […]

Stress, Immunity and Coronary Artery Disease

Stress, Immunity and Coronary Artery Disease

In this review Roger Ho and colleagues discuss how stress hormones through affecting different components of the immune/inflammatory reaction may in turn contribute to the development of coronary artery disease (CAD). Recent evidence indicates that acute and chronic psychological stress, such as intense anger, low socioeconomic status, work stress, social isolation, depression, anxiety and hostility […]

IL-27 and IFN-Gamma Cooperate to Induce Steroid Resistance in Asthma

IL-27 and IFN-Gamma Cooperate to Induce Steroid Resistance in Asthma

The mechanisms driving steroid resistance in asthma are poorly understood, but a new study published in Journal of Immunology indicates that a novel interleukin (IL)-27– and interferon (IFN)-γ–driven pathway may contribute to this process, where the activation of MyD88-dependent pathways in macrophages may play a critical role. The major downstream molecules that regulate IFN-gamma and […]

The Sympathetic Nervous System as a Regulator of Breast Cancer Metastasis

The Sympathetic Nervous System as a Regulator of Breast Cancer Metastasis

A study published in the journal Cancer Research identifies sympathetic nervous system (SNS) activation as a novel physiologic regulator of breast cancer metastasis to distant tissue sites. The effects of the neuroendocrine system and microenvironment on breast cancer metastasis remain largely unexplored. Sympathetic nervous system nerve fibers are present in organs that serve as key […]

Cold-Induced Sympathoexcitation and Adipokine Profiles in Humans

Cold-Induced Sympathoexcitation and Adipokine Profiles in Humans

A study published in the journal Metabolism suggests that the sympathetic nervous system (SNS) and its activation during cold-induced stress activation may play an important role in the regulation of adipokine secretion. Adipose tissue, in tight interconnection with the SNS, has a key role in maintaining energy homeostasis, blood pressure control, immunoregulation, hemostasis, and atherosclerosis. […]

A Combination of Beta-Adrenergic Antagonist and Cyclooxygenase-2 Inhibitor Improves Survival Rates in Murine Models of Postoperative Metastasis

A Combination of Beta-Adrenergic Antagonist and Cyclooxygenase-2 Inhibitor Improves Survival Rates in Murine Models of Postoperative Metastasis

A study published in the Journal of Immunology suggests that the combined blockade of excess release of catecholamines (CAs) and prostaglandins (PGs) in cancer patients undergoing tumor excision might improve survival rates and prevent cancer recurrence. The surgical procedure, a common step in the treatment of most solid cancers, has long been suspected to facilitate […]