Sleep participates in the regulation of several physiological processes such as energy metabolism, neural plasticity and immune functions. Sleep and immune responses are reciprocally and closely linked. Sleep abnormalities affect immunity, whereas, on the other hand, the immune response, activated for instance by an infection, alters sleep.
Sleep is also considered to be an important factor associated with the process of inflammation and sleep disturbances are linked to disease activity and health adverse risks.
On the other hand, sleep supports immune defense, and slow wave sleep (SWS) induces a pro-inflammatory milieu, conversely, pro-inflammatory cytokines feed back to the brain and enhance SWS.
Neuroimmunology of Sleep provides a comprehensive overview of the immune system’s effects on central nervous system functions, and particularly their impact on the regulation of sleep and wakefulness.
The book delivers both basic and clinical perspectives of the neuroimmunology of sleep and their influence on health and disease. The roles of various immune mediators and their effects on the central nervous system functions and sleep are discussed.
The chapters of Neuroimmunology of Sleep have been written by experts in this field. The book offers useful information to researchers and medical professionals, and medical and PhDs students.
384 pages; Springer; 2007 edition (March 31, 2012).
EDITORS: S. R. Pandi-Perumal, Daniel P. Cardinali and George P. Chrousos
S.R. Pandi-perumal, MSc., Comprehensive Center for Sleep Medicine, Department of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, U.S.A.
D.P. Cardinali, MD., PhD., Department of Physiology, Faculty of Medicine, University of Buenos Aires, Paraguay 2155, 1121, Buenos Aires, Argentina.
G.P. Chrousos, MD, FAAP, MACP, MACE, First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children’s Hospital, 115 27 Athens, Greece and Reproductive Biology and Medicine Branch, National Institute of Child and Human Development (NICHD), Bethesda, MD, USA.
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