Neuroimmune pharmacology is a relatively new discipline, however well-grounded on interdisciplinary basic and translational research in pharmacology, immunology and neuroscience, aiming at the therapeutic exploitation of the rapidly growing knowledge about physiology and pathology of nervous system-immune system interconnections.
The 2nd edition of Neuroimmune Pharmacology by Howard E. Gendelman and Tsuneya Ikezu (Editors) with Serge Przedborski, Eliezer Masliah and Marco Cosentino (Associate Editors) has been published in 2017, nearly 9 years after the 1st edition.
With more than one thousand pages (two hundred pages more than the previous edition), Neuroimmune Pharmacology provides a comprehensive and cutting edge picture of the tremendous progresses achieved in the understanding of the mutual interconnections among inflammation, immunity and neural control of disease, in the central nervous system as well as in periphery.
Take just Parkinson’s disease (PD) as an example. Up to only a few years ago, investigating the role of inflammation and peripheral immunity in PD would have been considered unreasonable by most neuroscientists and immunologists. At present however PD-associated neurodegeneration as a consequence of neuroinflammation in turn supported by peripheral T cells likely activated by peripheral leakage of a-synuclein is much more than a simple speculation, and innovative therapeutics targeting inflammation and immunity increasingly represent promising opportunities for PD patients.
New developments in PD, as well as in multiple sclerosis, Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, prion disease, HIV, drugs of abuse, autism spectrum disorders and many others are extensively discussed together with novel and emerging therapeutic strategies, including immunotherapies for neurodegenerative disorders, polymer nanomaterials for drug delivery in the central nervous system, gene therapy and vaccination.
With 56 chapters authored by prominent experts in their respective fields, Neuroimmune Pharmacology is organized into three parts, dedicated to Immunology of the Nervous System, Immunology of Neurodegenerative, Neuroinflammatory, Neuroinfectious and Neuropsychiatric Disorders, and Therapies and Diagnostics.
As a whole, the book is a standalone reference for preclinical and clinical researchers as well as for clinicians searching for a guidance into the rapidly developing interdisciplinary field of neuroimmune pharmacology.
Publisher: Springer; 2nd ed. 2017 edition (December 23, 2016); Hardcover: 1035 pages – ISBN 978-3-319-44020-0; eBook: ISBN 978-3-319-44022-4