Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases

Neuroimmune Circuits, Drugs of Abuse, and Infectious DiseasesNeuroimmune Circuits, Drugs of Abuse, and Infectious Diseases (Advances in Experimental Medicine and Biology) is published by Springer and edited by Herman Friedman, Thomas W. Klein and John J. Madden.

The book is based on the proceedings of the 7th annual symposium on the topic Neuroimmune Circuits, Infectious Diseases and Drugs of Abuse, held in Bethesda, Maryland, in October 1999.

The symposium focused on newer knowledge concerning the relationship between the immune and nervous systems with regards to the effects of drugs of abuse and infections, including AIDS, caused by the immunodeficiency virus.

Presentations discussed the brain-immune axis from the viewpoint of drugs of abuse rather than from the subject of the brain or immunity alone. The major aim of this series of conferences has been to clarify the consequences of immunomodulation induced by drugs of abuse in regards to susceptibility and pathogenesis of infectious diseases, both in man and in various animal model systems.

The use of drugs of abuse such as morphine, cocaine, and marijuana by large numbers of individuals around the world has continued to arouse serious concerns about the consequences of use of such drugs, especially on the normal physiological responses of an individual, including immune responses.

Much of the recent data accumulated by investigators show that drugs of abuse, especially opioids and cannabinoids, markedly alter immune responses in human populations as well as in experimental animals, both in vivo and in vitro.

Few selected chapters are listed below:

  • Targeting the Brain’s Immune System: A Psychopharmacological Approach to Central Nervous System Infections
  • Chemokine Receptors on Brain Endothelia – Keys to HIV-1 Neuroinvasion?
  • Direct vs. Indirect Modulation of Complex IN VITRO Human Retroviral Infections by Morphine
  • Interactions of Opioid Receptors, Chemokines, and Chemokine Receptors
  • Crosstalk Between Chemokine and Opioid Receptors Results in Downmodulation of Cell Migration
  • Role of Mu-opioid Receptor in Immune Function
  • Role of Beta-endorphin in the Modulation of Immune Responses: Perspectives in Autoimmune Diseases
  • Pharmaconeuroimmunology in the Intestinal Tract: Opioid and Cannabinoid Receptors, Enteric Neurons and Mucosal Defense
  • Downregulation of Cannabinoid Receptor 2 (CB2) Messenger RNA Expression During In Vitro Stimulation of Murine Splenocytes with Lipopolysaccharide
  • Effect of Cocaine on Chemokine and CCR- 5 Gene Expression by Mononuclear Cells from Normal Donors and HIV-1 Infected Patients
  • Intravenous Cocaine Abuse: A Rodent Model for Potential Interactions with HIV Proteins
  • Neuroaids: Retroviral Pathology and Drugs of Abuse

Paperback: 288 pages; Publisher: Springer

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