In 2014 we witnessed a rapid growth of the research and studies at the interface and intersection of neurosciences and immunology. This vast interdisciplinary area, often referred to as neuroendocrine immunology or neuroimmunology, also includes stress-immune interactions that may have complex and multifaceted impact on health and disease. Last year also brought some interesting developments and new conceptual trends to the field, and some of these were outlined here, on the BrainImmune site. What we feel stimulating and important is now highlighted and summarized below.
The TRPV1 receptor (transient receptor potential vanilloid type 1 ion channel) is a classical nociceptor or pain receptor. Samuel Bertin and colleagues, however, identified a ‘non-canonical’ function of the TRPV1 receptor. This includes its expression, involvement in TCR signaling and pro-inflammatory activities of T cells, and cytokine productionsuch as IFN-γ, IL-17A and TNF.