Evidence accumulated in the last 2-3 decades indicates that inflammation is an important pathogenic factor in depression. Also, some forms of depression are related to sustained increases in circulating proinflammatory cytokines.
Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder.
The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder.
Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder.
Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression.
The book synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry. It expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system. Also, it explores translational potential of targeting immune dysfunction for clinical interventions.
Some chapters of this book are listed below:
- Depression-Associated Cellular Components of the Innate and Adaptive Immune System
- Childhood Microbial Experience, Immunoregulation, Inflammation, and Adult Susceptibility to Psychosocial Stressors and Depression
- Neuroendocrine Abnormalities in Major Depression: An Insight Into Glucocorticoids, Cytokines, and the Kynurenine Pathway
- The Roles of T Cells in Clinical Depression
- Inflammasomes Action as an Important Mechanism in Experimental and Clinical Depression
- The Gut-Brain-Microbe Interaction: Relevance in Inflammation and Depression
- Childhood Trauma and Adulthood Immune Activation
- Epigenetic Changes in the Immune Systems Following Early-Life Stress
- Inflammation and Depression in Patients With Autoimmune Disease, Diabetes, and Obesity
- Depression Subtypes and Inflammation: Atypical Rather Than Melancholic Depression Is Linked With Immunometabolic Dysregulations
- Modulation of Inflammation by Antidepressants
Paperback: 636 pages; Publisher: Academic Press; 1 edition (June 9, 2018)