Psychological stress has been linked to a pro-inflammatory response in the brain characterized by a complex release of several inflammatory mediators such as cytokines, prostanoids and free radicals. Such response might contribute to cell damage during several psychiatric diseases related with stress. However, anti-inflammatory pathways are also activated in response to stress, constituting a possible endogenous mechanism of defense against excessive inflammation.
The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges – acutely and in the long-run.
Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry.
Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine and neurotransmitter systems and its corollaries regarding gene expression and behavioral processes such as cognition, motivation and emotionality.
Part 2 treats the complexity of short-term and long-term regulation of stress responsivity, the role of stress in psychiatric disorders as based on both preclinical and clinical evidence, and the current status with regard to new therapeutic strategies targeting stress-related disorders.
* Provides an overview of recent advances made in stress research
* Includes timely discussion of stress and its effect on the immune system
* Presents novel treatment strategies targeting brain processes involved in stress processing and coping mechanisms
Series: Techniques in the Behavioral and Neural Sciences; Hardcover: 1288 pages; Publisher: Elsevier Science; 1 edition (July 26, 2005).