Glucocorticoid Signaling: From Molecules to Mice to Man

glucorticoid signaling bookGlucocorticoid Signaling: From Molecules to Mice to Man (Advances in Experimental Medicine and Biology) is published by Springer and edited by Jen-Chywan Wang and Charles Harris.

Glucocorticoids, the steroid hormones secreted from the adrenal cortex zona fasciculate play numerous important roles in the maintenance of internal homeostasis by influencing activities of virtually all organs and tissues. Of note, glucocorticoids are essential in the body’s response to stress, and a complex but organized feedback system, called the hypothalamic-pituitary adrenal (HPA) axis, regulates the production of glucocorticoids.

Glucocorticoid Signaling: From Molecules to Mice to Man provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease.

This recent book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues.

The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.


  • Regulatory Actions of Glucocorticoid Hormones: From Organisms to Mechanisms

  • Molecular Biology of Glucocorticoid Signaling
  • Mechanisms of Glucocorticoid-Regulated Gene Transcription
  • Clinical Perspective: What Do Addison and Cushing Tell Us About Glucocorticoid Action?
  • Regulation of Glucose Homeostasis by Glucocorticoids
  • How Do Glucocorticoids Regulate Lipid Metabolism?
  • Glucocorticoids and Skeletal Muscle
  • Glucocorticoid-Induced Osteoporosis
  • Effects of Glucocorticoids in the Immune System
  • Glucocorticoids and the Brain: Neural Mechanisms Regulating the Stress Response
  • Glucocorticoid Regulation of Reproduction
  • Glucocorticoids and the Lung
  • Glucocorticoids and the Cardiovascular System
  • Glucocorticoids and Cancer
  • Animal Models of Altered Glucocorticoid Signaling
  • The Dehydrogenase Hypothesis
  • Conclusions and Future Directions

Series: Advances in Experimental Medicine and Biology (Book 872); Hardcover: 385 pages; Publisher: Springer; 1st ed. 2015 edition (July 28, 2015).

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amazon> Glucocorticoid Signaling: From Molecules to Mice to Man (Advances in Experimental Medicine and Biology)

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