BrainImmune: Trends in Neuroendocrine Immunology http://www.brainimmune.com Expert views & state of art in neuroendocrine immunology & stress-immunity research by BrainImmune.com. Both fundamental & clinical aspects and their impacts on health & disease. Mon, 25 Jun 2018 17:00:28 +0000 en-US hourly 1 https://wordpress.org/?v=4.9.6 107933628 Neuroimmune Pharmacology 2nd Edition http://www.brainimmune.com/neuroimmune-pharmacology-2nd-edition/ Mon, 18 Jun 2018 11:55:55 +0000 http://www.brainimmune.com/?p=6507 Neuroimmune pharmacology is a relatively young discipline, however well-grounded on interdisciplinary basic and translational research in pharmacology, immunology and neuroscience, aiming at the therapeutic exploitation of the rapidly growing knowledge about physiology and pathology of nervous system-immune system interconnections. The Society on Neuroimmune Pharmacology was founded in1993, while the first issue of the Journal of […]

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Neuroimmune Pharmacology 2nd EditionNeuroimmune pharmacology is a relatively young discipline, however well-grounded on interdisciplinary basic and translational research in pharmacology, immunology and neuroscience, aiming at the therapeutic exploitation of the rapidly growing knowledge about physiology and pathology of nervous system-immune system interconnections. The Society on Neuroimmune Pharmacology was founded in1993, while the first issue of the Journal of Neuroimmune Pharmacology was published in March 2006.

The 2nd edition of Neuroimmune Pharmacology by Howard E. Gendelman and Tsuneya Ikezu (Editors) with Serge Przedborski, Eliezer Masliah and Marco Cosentino (Associate Editors) has been published in 2017, nearly 9 years after the 1st edition.

With more than one thousand pages (two hundred pages more than the previous edition), Neuroimmune Pharmacology provides a comprehensive and cutting edge picture of the tremendous progresses achieved in the understanding of the mutual interconnections among inflammation, immunity and neural control of disease, in the central nervous system as well as in periphery.

Take just Parkinson’s disease (PD) as an example. Up to only a few years ago, investigating the role of inflammation and peripheral immunity in PD would have been considered unreasonable by most neuroscientists and immunologists. At present however PD-associated neurodegeneration as a consequence of neuroinflammation in turn supported by peripheral T cells likely activated by peripheral leakage of a-synuclein is much more than a simple speculation, and innovative therapeutics targeting inflammation and immunity increasingly represent promising opportunities for PD patients.

New developments in PD, as well as in multiple sclerosis, Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, prion disease, HIV, drugs of abuse, autism spectrum disorders and many others are extensively discussed together with novel and emerging therapeutic strategies, including immunotherapies for neurodegenerative disorders, polymer nanomaterials for drug delivery in the central nervous system, gene therapy and vaccination.

With 56 chapters authored by prominent experts in their respective fields, Neuroimmune Pharmacology is organized into three parts, dedicated to Immunology of the Nervous System, Immunology of Neurodegenerative, Neuroinflammatory, Neuroinfectious and Neuropsychiatric Disorders, and Therapies and Diagnostics.

As a whole, the book is a standalone reference for preclinical and clinical researchers as well as for clinicians searching for a guidance into the rapidly developing interdisciplinary field of neuroimmune pharmacology.

Few selected chapters of Neuroimmune Pharmacology are listed below:

  • Hippocampus, Spatial Memory and Neuroimmunomodulation
  • Immune Sensors and Effectors of Health and Disease
  • Stem Cells and Neurogenesis for Brain Development, Degeneration and Therapy
  • Growth and Neurotrophic Factors in HIV-Associated Neurocognitive Disorders
  • Neurodegeneration
  • HIV-Associated Neurocognitive Disorders
  • Neuroimmunomodulation of Human T-Lymphotrophic Virus Type I/II Infection
  • Alzheimer’s Disease
  • Neurogenesis and Brain Repair
  • The Neuroimmune System in Psychiatric Disorders
  • Therapeutic Strategies in Neurodegenerative Diseases
  • Therapeutic Considerations in HIV-Associated Neurocognitive Disorders

Hardcover: 1035 pages; Publisher: Springer; 2nd ed. 2017 edition (December 23, 2016)


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Neuroimmune Pharmacology

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Rethinking Homeostasis: Allostatic Regulation in Physiology and Pathophysiology http://www.brainimmune.com/rethinking-homeostasis-allostatic-regulation-physiology/ Fri, 15 Jun 2018 14:54:08 +0000 http://www.brainimmune.com/?p=6467 Rethinking Homeostasis: Allostatic Regulation in Physiology and Pathophysiology is published by A Bradford Book and authored by Jay Schulkin. Homeostasis as a concept and term was introduced by the American physiologist WalterCannon and refers to the stability of the inner world, or the various bodily states that make up the internal environment. Examples include for […]

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Rethinking Homeostasis Allostatic Regulation PhysiologyRethinking Homeostasis: Allostatic Regulation in Physiology and Pathophysiology is published by A Bradford Book and authored by Jay Schulkin.

Homeostasis as a concept and term was introduced by the American physiologist WalterCannon and refers to the stability of the inner world, or the various bodily states that make up the internal environment. Examples include for example temperature regulation and oxygen consumption Homeostasis, was a direct extension from Claude Bernard’s of the milieu intérieur.

According to Cannon, the brain coordinates body systems, with the aim of maintaining a set of goal values for key internal variables. Internal or external disturbances threatening homeostasis, by causing large enough deviations from the goal values, arouse internal nervous and hormone systems, induce emotional and motivational states, and generate externally observable behaviors, all of which have the goal of reestablishing homeostasis. According to the more recent concept of allostasis, however, no single set of ideal values exists for levels of internal variables.

In Rethinking Homeostasis Jay Schulkin discusses that when an organism is under stress, the central nervous system works with the endocrine system to use resources to maintain the overall viability of the organism. The process accelerates the various systems’ defenses of bodily viability, but can violate short-term homeostasis. This allostatic regulation highlights our ability to anticipate, adapt to, and cope with impending future events.

Focusing on the concept of motivation and its relationship to the central nervous system function and specific hormonal systems, Jay Schulkin applies a neuroendocrine perspective to central motive states such as cravings for water, sodium, food, sex, and drugs. He examines in detail the bodily consequences of the behavioral and neuroendocrine regulation of fear and adversity, the endocrine regulation of normal and preterm birth, and the effects of drug addiction on the body. Schulkin’s presentation of allostasis lays the foundation for further study.

Book’s chapters are listed below:

  1. Allostasis: The Emergence of a Concept
  2. Central Motive States: Feedforward Neuroendocrine Systems in the Brain
  3. Anticipation, Angst, Allostatic Regulation: Adrenal Steroid Regulation of Corticotropin-Releasing Hormone
  4. Normal and Pathological Facilitation of Parturition by a Feedforward Endocrine Mechanism
  5. Addiction to Drugs: Allostatic Regulation under Duress

Series: MIT Press Hardcover: 288 pages; Publisher: A Bradford Book (January 31, 2003)


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Rethinking Homeostasis: Allostatic Regulation in Physiology and Pathophysiology

See also:

The Wisdom Of The Body
Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine

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Pain and Neuroimmune Interactions http://www.brainimmune.com/pain-neuroimmune-interactions/ Wed, 13 Jun 2018 17:05:39 +0000 http://www.brainimmune.com/?p=6464 Pain and Neuroimmune Interactions is published by Springer and edited by Nayef E. Saade, Nayef E. Saadé, Suhayl J. Jabbur and A. Vania Apkarian. Pain is a product of various pathways and mechanisms within the nervous system in response to inflammation or trauma. Over 1.5 billion people suffer from chronic pain with 3-4.5% of the […]

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Pain and Neuroimmune InteractionsPain and Neuroimmune Interactions is published by Springer and edited by Nayef E. Saade, Nayef E. Saadé, Suhayl J. Jabbur and A. Vania Apkarian.

Pain is a product of various pathways and mechanisms within the nervous system in response to inflammation or trauma. Over 1.5 billion people suffer from chronic pain with 3-4.5% of the global population suffering specifically from neuropathic pain, and the incidence is increasing complementary to age.

Recent research indicates that the sensation of pain and suffering could be considered as part of a mechanism that involves not only sizeable areas in the brain but also simultaneous activations of the immune and the endocrine systems as well.

An increasing body of evidence suggests that pain involves different neural, immune and endocrine mechanisms that interact at peripheral and central levels. Furthermore, chronic pain could then be looked upon as a corollary of the imbalance in the cross talk between these systems, which could lead to new treatment strategies.

The aim of this book is not to deal with acute pain that serves as an alarm signal, but to attempt to explain the molecular mechanisms of chronic pain considered as a multifactorial syndrome or disease.

The chapters of this book are shown below:

  • Nociceptor Excitation by Sensitization: A Novel Hypothesis, Its Cellular and Molecular Background by Reeh, Peter W. (et al.)
  • Tachykinins in Visceral Pain and Hyperalgesia by Cervero, Fernando (et al.)
  • Bradykinin, Cytokines and Inflammatory Hyperalgesia by Poole, Stephen (et al.)
  • Neurotransmitter and Inflammatory Correlates in Experimental Neuropathy: Modulation by Electric Spinal Cord Stimulation by Linderoth, Bengt (et al.)
  • Diffuse Noxious Inhibitory Controls and Arthritis in the Rat by Danziger, Nicolas (et al.)
  • NSAIDs and Some Safe Strategies of Their Use: Spinal C-Fos Protein Studies in Carrageenan Model of Inflammatory Nociceptive Processes by Buritova, Jaroslava (et al.)
  • The Role of Dorsal Root Reflexes in Neurogenic Inflammation and Pain by Willis, William D. (et al.)
  • Pain and Neurogenic Inflammation: A Neural Substrate for Neuroendocrine-Immune Interactions by Saadé, Nayef E. (et al.)
  • Thymic Peptides: Transmitters Between the Neuroendocrine and the Immune System by Dardenne, Mireille (et al.)
  • Thymulin and Inflammatory Pain: A Possible Substrate for Pge-2 Dependent Neuroimmune Loop by Safieh-Garabedian, Bared (et al.)
  • The Role of Peripheral and Brain-Borne Cytokines in Immune-Neuro-Endocrine Interactions by Besedovsky, Hugo O. (et al.)
  • Interleukin-1 Receptors and Ligands in the Nervous System by Haour, France (et al.)
  • Biphasic Modulation of Pain by Hypothalamic Cytokines by Hori, T. (et al.)
  • In Search of Pain Consciousness or Pain and the Metaphysics of a Porsche 911 by Apkarian, A. Vania
  • How Do Strokes Cause Pain? by Tasker, Ronald R.
  • Chronic Pain: Somatic or Limbic Mechanisms by Jabbur, Suhayl J. (et al.)
  • Where Would One Seek Links Between the Nervous and Immune Systems? by Wall, Patrick D.

Hardcover: 244 pages; Publisher: Springer; 2000 edition (April 30, 2000)


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Pain and Neuroimmune Interactions (2013-03-01)

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Immunoendocrinology: Scientific and Clinical Aspects http://www.brainimmune.com/immunoendocrinology-scientific-clinical-aspects/ Sat, 09 Jun 2018 13:11:16 +0000 http://www.brainimmune.com/?p=6419 Immunoendocrinology: Scientific and Clinical Aspects is published by Humana Press and edited by George S. Eisenbarth. The book is focused on autoimmune disorders, and particularly, endocrine autoimmune diseases. With the exception of celiac disease, the environmental factors that contribute to the onset, development and the marked increase in many of these disorders remain poorly understood. […]

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Immunoendocrinology Scientific Clinical AspectsImmunoendocrinology: Scientific and Clinical Aspects is published by Humana Press and edited by George S. Eisenbarth. The book is focused on autoimmune disorders, and particularly, endocrine autoimmune diseases.

With the exception of celiac disease, the environmental factors that contribute to the onset, development and the marked increase in many of these disorders remain poorly understood.

Immunoendocrinology: Scientific and Clinical Aspects outlines the central role of immune-endocrinologic processes in the pathogenesis of type 1 diabetes and several other autoimmune and endocrine disorders.

This fundamental and clinical field has played a prominent role in advancing the understanding of autoimmunity including creation of the first models of induced autoimmune disease, demonstration that autoimmunity can cause human pathology, and characterization of remarkable syndromes linking multiple autoimmune diseases.

Some of the book’s chapters are highlighted below:

  • Discovering Novel Antigens
  • Characterizing T-Cell Autoimmunity
  • Metabolic Syndrome and Inflammation
  • The Mouse Model of Autoimmune Polyglandular Syndrome Type 1
  • Autoimmune Polyendocrine Syndrome Type I: Man
  • IPEX Syndrome: Clinical Profile, Biological Features, and Current Treatment
  • Autoimmune Polyendocrine Syndrome Type 2: Pathophysiology, Natural History, and Clinical Manifestations
  • Drug-Induced Endocrine Autoimmunity
  • Immunopathogenesis of the NOD Mouse
  • Virus-Induced Type 1 Diabetes in the Rat
  • Autoimmune Pathology of Type 1 Diabetes
  • Natural History of Type 1 Diabetes
  • Immunotherapy of Type-1 Diabetes: Immunoprevention and Immunoreversal
  • Latent Autoimmune Diabetes in Adults
  • Fulminant Type 1 Diabetes Mellitus
  • Insulin Autoimmune Syndrome (Hirata Disease)
  • Lessons from Patients with Anti-Insulin Receptor Autoantibodies
  • Addison’s Disease
  • Animal Models of Autoimmune Thyroid Disease
  • Immunopathogenesis of Thyroiditis
  • Immunopathogenesis of Graves’ Disease
  • Graves’ Ophthalmopathy
  • Hypoparathyroidism
  • Premature Gonadal Insufficiency
  • Celiac Disease and Intestinal Endocrine Autoimmunity
  • Pituitary Autoimmunity

Series: Contemporary Endocrinology; Paperback: 579 pages; Publisher: Humana Press; Softcover reprint of the original 1st ed. 2011 edition (August 23, 2016)


Related stories you may like:

Brain superautoantigens: connections between immune and neural repertoires
Stress and organ specific autoimmunity: a complex interrelationship
Caleb Parry hyperthyroidism and stress
Stress-induced Th2 shift and thyroid autoimmunity


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Immunoendocrinology: Scientific and Clinical Aspects (Contemporary Endocrinology) (2010-12-13)

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Bodily Changes in Pain, Hunger, Fear and Rage: An Account of Recent Researches into the Function of Emotional Excitement http://www.brainimmune.com/bodily-changes-pain-hunger-fear-and-rage/ Mon, 04 Jun 2018 12:34:35 +0000 http://www.brainimmune.com/?p=6289 ‘Bodily Changes in Pain, Hunger, Fear and Rage’ is authored by Walter Bradford Cannon, an American physician-scientist and physiologist, chairman (1906-1942) of the Department of Physiology at Harvard Medical School, who introduced, developed and popularized three ideas and concepts that are well known and widely accepted: homeostasis, fight-or-flight responses, and the sympathoadrenal system. Early in […]

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Bodily Changes Pain Hunger Fear and RageBodily Changes in Pain, Hunger, Fear and Rage’ is authored by Walter Bradford Cannon, an American physician-scientist and physiologist, chairman (1906-1942) of the Department of Physiology at Harvard Medical School, who introduced, developed and popularized three ideas and concepts that are well known and widely accepted: homeostasis, fight-or-flight responses, and the sympathoadrenal system.

Early in his career, Cannon noticed that the adrenal medulla function is linked to the sympathetic nervous system and many physiological changes associated with emotional arousal. This includes dilation of the pupils, fast pulse, piloerection, and inhibition of gastrointestinal function, all signs of an increased sympathetic nervous system activity.

In 1909, Cannon noted the marked sensitivity of the stomach and intestines to psychological stimuli. In 1911, he also observed that a cat, placed in a holder, and frightened, released detectable amounts of “adrenalin”, and concluded that the general nature of the cat’s responses when frightened were “all signs of nervous discharges along sympathetic paths”. Later, in 1914, Cannon proposed the ‘emergency function’ theory of the adrenal-medulla function.

Thus, in 1915, in his renowned book Bodily Changes in Pain, Hunger, Fear and Rage: An Account of Recent Researches into the Function of Emotional Excitement, he coined the term ‘fight-or-flight’ response, describing the animal’s response to threats.

Bodily Changes Pain Hunger Fear Rage OriginalAs per Cannon, at large, animals react to threats with a general activation of the sympathetic nervous system, priming the animal for fighting or fleeing, and that “it is the sympathetic division of the autonomic system which is the primary agency in mobilizing the bodily forces in times of great fear or rage”.

This served as a basis for his concepts of homeostasis. In fact, Cannon invented the word homeostasis. By this term he referred to the stability of the inner world. The concept of homeostasis therefore was a direct extension from Claude Bernard’s idea of the milieu intérieur, and Cannon popularized it in his book ‘The Wisdom of the Body’ in 1932.

Cannon presented four tentative propositions to describe the general features of homeostasis: Constancy in an open system, such as our bodies represent, requires mechanisms that act to maintain this constancy.

Steady-state conditions require that any tendency toward change automatically meets with factors that resist change. The regulating system that determines the homeostatic state consists of a number of cooperating mechanisms acting simultaneously or successively. And, homeostasis does not occur by chance, but is the result of organized self-government.

Paperback: 326 pages; Publisher: Martino Fine Books (December 7, 2016). ‘Bodily Changes in Pain, Hunger, Fear and Rage’ is the 2016 Reprint of the 1925 Edition, and represents a full facsimile of the original edition, not reproduced with Optical Recognition Software.


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Bodily Changes in Pain, Hunger, Fear and Rage: An Account of Recent Researches Into the Function of Emotional Excitement

See also:

The Wisdom Of The Body

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An Introduction to the Study of Experimental Medicine http://www.brainimmune.com/introduction-study-experimental-medicine/ Wed, 30 May 2018 14:28:48 +0000 http://www.brainimmune.com/?p=6284 An Introduction to the Study of Experimental Medicine, a masterpiece and a classic book which is still read, is written by Claude Bernard, the father of modern physiology and experimental medicine. In 1865, forced by sickness to abandon his teaching and research activities, Bernard wrote this book, establishing as general principles his thoughts about experimentation […]

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An Introduction the Study Experimental MedicineAn Introduction to the Study of Experimental Medicine, a masterpiece and a classic book which is still read, is written by Claude Bernard, the father of modern physiology and experimental medicine.

In 1865, forced by sickness to abandon his teaching and research activities, Bernard wrote this book, establishing as general principles his thoughts about experimentation in physiology and medicine. The book represents a clear and penetrating presentation of the basic principles of medical research from this great French physiologist.

It was said of Claude Bernard, “he is not merely a physiologist, he is physiology”. Alexis Carel also said of Bernard: “Before him, medicine was purely empirical. He is responsible for the introduction of the scientific method in the art of healing”.

The ‘Introduction’ was written by Bernard at a “period of his scientific career when grouping of facts and theorizing began to take precedence over noting of details………Medicine has passed through the empiric, the systematic, the nosologic and the morphologic stages and has now entered the experimental stage. Bernard envisioned physiology as the foundation of experimental medicine and a larger part of biology”.

Claude Bernard’s contemporary and his good friend, Louis Pasteur wrote about the ‘Introduction’: “Nothing so complete, nothing so profound and so luminous has ever been written on the true principles of the difficult art of experimentation. This book will exert an immense influence on medical science, its teaching, its progress….”

An Introduction the Study Experimental Medicine OriginalIn his book Bernard introduced some major principles of modern experimental medicine such as: Truth versus Falsification; Determinism and Averages; Authority and Observation; Induction and Deduction; Fallibility; Cause and Effect; Known and Unknown and Discovering vs. Despising.

He wrote:

“When we meet a fact which contradicts a prevailing theory, we must accept the fact and abandon the theory, even when the theory is supported by great names and generally accepted”.

And:

“The complete scientist is one who masters both theory and experimental practice: 1, he observes a fact; 2, he conceives an idea with reference to this fact; 3, on the basis of this idea he pursues a line of reasoning, plans an experiment and imagines and organizes its material conditions; 4, this experiment produces more phenomena that shall be subjected to observation and so on. In a sense, the scientist’s mind is always between two observations: one is the starting point of the reasoning, the other its conclusion”.

In the ‘Introduction’ Bernard also brought the concept of the constancy of the internal environment or ‘milieu intérieur’ and wrote that “La fixité du milieu intérieur est la condition d’une vie libre et indépendante” (“The constancy of the internal environment is the condition required for a free and independent life“). Bernard was well aware that anatomy remained the basis of physiology, but he made it clear that physiological processes cannot be explained on the basis of the sole anatomy.

This new concept entailed the overcoming of the concept of physiology as ‘anatomy in motion’ and a radical shift in perspective.

The concept of the constancy of the internal environment was further developed about 50-60 years later by the American physiologist Walter Cannon, coining the term and advancing the concept of homeostasis.

Series: Dover Books on Biology; Paperback: 272 pages; Publisher: Dover Publications (June 1, 1957).


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An Introduction to the Study of Experimental Medicine (Dover Books on Biology)

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Neural-Immune Interactions in Brain Function and Alcohol Related Disorders http://www.brainimmune.com/neural-immune-interactions-alcohol-related-disorders/ Mon, 28 May 2018 13:10:10 +0000 http://www.brainimmune.com/?p=6280 Neural-Immune Interactions in Brain Function and Alcohol Related Disorders presents the recent advances in neuro-immune and alcohol research, relevant to brain function, behavior and alcohol use disorders.  Recent up-to-date and cutting edge development is provided by experts in the field of neuroendocrine-immunology and alcohol use disorders. Neuroendocrine-immunology and neural-immune interactions offer a new framework for […]

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Neural-Immune Interactions Alcohol Related DisordersNeural-Immune Interactions in Brain Function and Alcohol Related Disorders presents the recent advances in neuro-immune and alcohol research, relevant to brain function, behavior and alcohol use disorders.  Recent up-to-date and cutting edge development is provided by experts in the field of neuroendocrine-immunology and alcohol use disorders.

Neuroendocrine-immunology and neural-immune interactions offer a new framework for understanding neurodevelopment and a variety of neurological disorders. The progress in this relatively new interdisciplinary field has a far reaching impact on many areas of neuroscience, including alcohol research. Studies using human alcoholic brains, gene knockout mice, and gene expression profiling have established a clear link between alcoholism and altered neuroimmune profiles.

Neural–Immune Interaction in Brain Function and Alcohol Related Disorders focuses on neural-immune interactions in areas directly related to alcohol use disorders. However, research topics such as sleep disorders, pain, and cholinergic anti-inflammatory pathways are not covered as independent chapters but briefly mentioned in the text. The close relevance of these topics to neural-immune interactions and alcohol use disorders warrants future discussion and more research efforts.

Few selected chapters are listed below:

  • Neuroimmune Modulation of Synaptic Function
  • Neuroimaging and Clinical Studies on Brain–Immune Interactions
  • Mechanisms of Stress-Dependent Neuroinflammation and Their Implications for Understanding Consequences of Alcohol Exposure
  • Neuroimmune Cross Talk and HIV-Associated Neurocognitive Disorders
  • Innate Immune Signaling and Alcoholism
  • Role of Toll-Like Receptor 4 in Alcohol-Induced Neuroinflammation and Behavioral Dysfunctions
  • Prenatal Alcohol Exposure: Impact on Neuroendocrine–Neuroimmune Networks
  • Neuroimmune Mechanisms of Glia and Their Interplay with Alcohol Exposure Across the Lifespan
  • Effects of Morphine and Alcohol on the Hypothalamic–Pituitary–Adrenal Axis, Immunity, and Cognitive Behavior
  • Therapeutic Strategies to Treat Alcohol-Related Disorders Targeting Central Immune Signaling
  • Alcohol and the Neuroimmune Response: Current Status and Future Directions

Hardcover: 588 pages; Publisher: Springer; 2013 edition (October 25, 2012)

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The Physiology of Immunity http://www.brainimmune.com/physiology-immunity/ Fri, 25 May 2018 17:32:47 +0000 http://www.brainimmune.com/?p=6277 The Physiology of Immunity (Comparative Immunology) provides an overview of the immune system and integrates physiology and immunology, outlining the effects of the neuroendocrine system on immunity, and comparing the neuroendocrine-immune function of a variety of species. Neuroendocrine-immunology or immunophysiology has become a highly visible and fast-growing area in modern inter-disciplinary research. This book’s sections […]

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he Physiology of ImmunityThe Physiology of Immunity (Comparative Immunology) provides an overview of the immune system and integrates physiology and immunology, outlining the effects of the neuroendocrine system on immunity, and comparing the neuroendocrine-immune function of a variety of species.

Neuroendocrine-immunology or immunophysiology has become a highly visible and fast-growing area in modern inter-disciplinary research. This book’s sections focus on the neuroendocrine regulation of the immune system in conditions such as reproduction, pregnancy, stress and aging.

The text is organized in seven sections, beginning with an introduction to the immune system. Section II outlines how the central nervous system (CNS) communicates with central and peripheral lymphoid organs. Section III provides information on factors from the immune system that act as messengers to the CNS. The metabolic regulation of growth and development is discussed in Section IV. Section V examines the interactions occurring between the reproductive and immune systems.

The effects of other physiologic stressors on immunity are reviewed in Section VI. Section VII considers cyclic and periodic influences on the immune system. Finally, there is a consideration of a new unifying theory for immunology.

Selected chapters are highlighted below:

  • Neuropeptides and the Immune System
  • Mediators of CNS Activity-Neuroendocrine-Immune (NEI) Interactions
  • Peripheral and Central Neural Mechanisms for Immune Regulation through the Innervation of Immune Effector Sites
  • The Role of Calcitonin Gene-Related Peptide (CGRP) and Other Sensory Neuropeptides in Modulating Inflammation and Immunity
  • CNS Biogenic Amines and the Immune System,
  • The Neuroendocrine Activity of the Thymus
  • Effects of Growth Hormone, Insulin-Like Growth Factor-I (IGF-I) and Somatostatin on Immune Function and Development
  • Interactions between the Thyroid and the Immune System
  • Estrogen-Mediated Interactions between the Immune and Female Reproductive Systems
  • The Role of Androgens-Androgen Receptor on Immune System Activity
  • Unique Neuroendocrine-Immune Interactions during Pregnancy
  • Stress and Neuroendocrine-Immune Interactions
  • The Hypothalamic-Pituitary-Adrenocortical Immune Axis
  • Circadian Rhythms and Immunity: T-Helper-2 Cells as Targets of the Circadian Melatonin Signal
  • Aging and Immunity

Hardcover: 464 pages; Publisher: CRC Press; 1 edition (September 30, 1996)

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The Neuroendocrine Immune Network http://www.brainimmune.com/neuroendocrine-immune-network/ Fri, 25 May 2018 12:29:31 +0000 http://www.brainimmune.com/?p=6271 The Neuroendocrine Immune Network is published by CRC Press and edited by Serem Freier, German, British and Israeli pediatrician and medical educator. The book’s major focus is neuroendocrine-immunology or the interactions between the nervous, endocrine and immune systems. It addresses the anatomical basis of these interactions, including the innervation of lymphoid tissues and mast cells, […]

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The Neuroendocrine Immune Network 1989The Neuroendocrine Immune Network is published by CRC Press and edited by Serem Freier, German, British and Israeli pediatrician and medical educator.

The book’s major focus is neuroendocrine-immunology or the interactions between the nervous, endocrine and immune systems.

It addresses the anatomical basis of these interactions, including the innervation of lymphoid tissues and mast cells, and the neuropeptide and neurotransmitter effects on the immune system.

The book also covers the mechanisms of signaling between cells, the effects of lesioning the brain, and the ways in which stress can affect the immune responses.

Emphasis is given to opioids, substance P, neurotensin, vasoactive intestinal peptide, somatostatin and cholecystokinin.

Also addressed is the immunoregulatory effect of leukotrienes and platelet-activating factors.

The cover from the 2017 edition of The Neuroendocrine Immune Network is shown below.The Neuroendocrine Immune Network 2017

The book contains 16 chapters by well-known research groups which review our current understanding of neuroendocrine control of immunological functions. Some chapters are listed below:

  • The Role of the Neural Crest in the Development of the Immune System and Endocrine Glands
  • Peripheral Innervation of Lymphoid Tissue
  • The Innervation of Mast Cells
  • Reciprocal Interactions Between Mast Cells and the Endocrine System
  • Signaling Pathways of the Neurotransmitter-Immune Network
  • Hypothalmic-Immune Interactions: Modulation of Immune Function by Electrolytic and Chemical Lesions of the Central Nervous Systems
  • Immunoregulatory Activity of Endogenous Opioids
  • Stress Neuropeptides, Immunity, and Neoplasia
  • Modulation of Phagocyte Activity by Substance P and Neurotensin
  • The Role of Substance P, Somatostatin and Vasoactive Intestinal Peptide in Modulation of Mucosal Immunity
  • Hormonal Influence on the Secretory Immune System of the Eye
  • The Neuroendocrine-Immune Network in the Gastrointestinal Tract

This work is of particular value to those in immunology, endocrinology, gastroenterology, and developmental biology.

Hardcover: 280 pages; Publisher: CRC Press; 1 edition (December 21, 1989)

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Neural Modulation of Immunity http://www.brainimmune.com/neural-modulation-immunity/ Tue, 22 May 2018 17:45:42 +0000 http://www.brainimmune.com/?p=6266 by Vincent Geenen, MD, PhD, University of Liege, Belgium Neural Modulation of Immunity was published in 1985 by Raven Press and was edited by Roger Guillemin, Melvin Cohn, and Theodore Melnechuk. This book presents the proceedings and active discussions of an international symposium held in Brussels (Belgium) under the auspices of the Princess Liliane Cardiology […]

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by Vincent Geenen, MD, PhD, University of Liege, Belgium

Neural Modulation of ImmunityNeural Modulation of Immunity was published in 1985 by Raven Press and was edited by Roger Guillemin, Melvin Cohn, and Theodore Melnechuk.

This book presents the proceedings and active discussions of an international symposium held in Brussels (Belgium) under the auspices of the Princess Liliane Cardiology Foundation, October 27 and 28, 1983.

After a general Introduction to immunology by Melvin Cohn, it contains 14 chapters that were written by pioneers in this new field of close interactions between the nervous, endocrine, and immune systems.

The first three chapters are devoted to the state of knowledge in psychoneuroimmunology at that time (Robert Ader, Marvin Stein, and Jan E.W. Palmblad).

The anatomical and chemical relationships are discussed in the six next chapters written by prominent experts in this field like Peter O. Behan and Norman Geshwind (Hemispheric laterality and immunity), the late Gérard Renoux, Tomas L. Roszman, Karen Bulloch (Neuroanatomy of lymphoid tissue), Nicholas R. Hall and Allan Goldstein (Neurotransmitters and host defense), and the late Joseph Wybran (Enkephalins, endorphins, substance P and the immune system).

Two chapters are devoted to immunological-neuroendocrine feedback circuits (Hugo Besedovsky, Adriana del Rey and Ernst Sorkin), and to the effects of thymic hormone on the brain and neuroendocrine circuits (Nicholas R. Hall, Joseph P. McGillis, Bryan L. Spangelo, David L. Healy, George P. Chrousos and Allan L. Goldstein).

Conceptual perspectives were addressed in the last three chapters: Properties of the specific immune system in relation to its possible regulation by the central nervous system (Hans Wigzell); Immunoregulatory and morphostatic function of bone marrow-derived factors (Walter Pierpaoli); and Microenvironmental factors in phenotypic expression by enteric neurons: Parallels to lymphocytes (Michael D. Gershon).

I was a young physician-scientist and I did not have the chance to attend this symposium, which has paved with others the fruitful way for the current success of a completely novel type of research field. Nevertheless, my Mentor, the late Paul Franchimont, gave me these proceedings together with those words: “Dear Vincent, this the way for your future research!”

Hardcover: 252 pages; Raven Press (1985) – ISBN0-88167-049-9

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