Homeostasis within the immune system is largely dependent on cytokines, the chemical messengers between immune cells. These diverse groups of proteins may be regarded as hormones of the immune system that play crucial roles in regulating immune and inflammatory responses.
Pro-inflammatory cytokines, released during an immune response and inflammation activate the central components of the stress system, alter neurotransmitter networks and sleep patterns or neuronal connectivity and social behavior. Vice versa, stress hormones affect all major immune functions including cytokine patterns and profiles, and immune cells traffic and redirection to immune/inflammatory sites. Clinically, cytokines are also implicated in autoimmunity, chronic pain, major depression and anxiety or Alzheimer’s disease.
The new edition of Cytokines: Stress and Immunity covers the cytokine involvement in the immune system’s response to stress and in a variety of mental and physical diseases.
Completely rewritten by the top authorities in their fields, this volume includes 16 entirely new chapters. It provides a comprehensive overview of the role of cytokines in the neuroendocrine and immune systems, while also addressing the interactions between these systems. It examines cytokine activity and clinical implications from a number of perspectives, including those of immunology, pharmacology, oncology, endocrinology, and psychiatry.
This new edition begins with an extended dedication and tribute to the late Robert A. Good. It documents the life and groundbreaking achievements of Dr. Good who served as an editor for both the former and current editions of this work.
Details all clinically relevant cytokines, including interleukins, interferons, enkephalins, and endorphins
Explores cytokine-hormone interactions and the clinical implications of those interactions on the immune, endocrine, and central nervous systems
Reviews the documented behavior effects of cytokine activity
Considers genetic predispositions toward cytokine activity
Discusses the role of interferon in health and disease
Examines the clinical relevance of opioid-induced immonosuppression
Hardcover: 405 pages
Publisher: CRC Press; 2 edition (October 10, 2006)
Editors: Robert E. Faith, Anthony J. Murgo, Robert A. Good, Nicholas P. Plotnikoff