Commentaries

Comments on Selected Articles in the Field

First Evidence That Th22 Cells May Contribute To the Pathogenesis of Graves’ Disease

First Evidence That Th22 Cells May Contribute To the Pathogenesis of Graves’ Disease

Commentary on the study by Di Peng et al., PLoS One. 2013 Jul 11;8(7):e68446 A High Frequency of Circulating Th22 and Th17 Cells in Patients with New Onset Graves’ Disease The many immune mechanisms involved in the onset and development of autoimmune diseases make their pathophysiology heterogeneous and complex. Among them, CD4+ T cells play […]

IL-17: A Promising Therapeutic Target in Several Chronic Inflammatory Diseases

IL-17: A Promising Therapeutic Target in Several Chronic Inflammatory Diseases

Commentary on the study by Dominique L. P. Baete and Vijay K. Kuchroo Nat Med. 2013 Jul;19(7):824-5 How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases Since the discovery of T helper 17 (Th17) cells, an increasing body of evidence indicates that these cells play a major role in the development […]

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

A Hierarchical Cytokines Framework Defining Groups of Chronic Inflammatory Diseases: Learning From Cytokine-Targeted Therapies

Commentary on the study by George Schett et al, Nat Med, 2013 Jul;19(7):822-4 How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy Extensive genome-wide association and epidemiological studies have shed light on the causes of chronic inflammatory diseases and have confirmed a central role of the immune system and particularly of cytokines [1]. Secreted […]

Oxytocin and Williams Syndrome: Exploring Neurobiology of Social Behavior

Oxytocin and Williams Syndrome: Exploring Neurobiology of Social Behavior

Commentary on the study by Li Dai et al., PLoS One. 2012;7(6):e38513 Oxytocin and Vasopressin Are Dysregulated in Williams Syndrome, a Genetic Disorder Affecting Social Behavior Quote from the original paper’s abstract “Results revealed significantly higher median levels of oxytocin (OT) in Williams syndrome (WS) versus controls at baseline, with a less marked increase in arginine […]

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