Neuroendocrine Immunology News

Neuroendocrine immunology news on novel advances in the field bridging neurosciences and immunology

Experimental Study Shows Link between Cerebrospinal Fluid IL-6 and Depressive Symptoms in Humans

Experimental Study Shows Link between Cerebrospinal Fluid IL-6 and Depressive Symptoms in Humans

A recent study published in Molecular Psychiatry suggests that the appearance of depressive symptoms in inflammatory conditions might be primarily linked to an increase in central IL-6 concentration. Inflammation is a physiological response to infection and tissue injury that involves the release of pro-inflammatory (e.g., TNF-α, IL-6) and anti-inflammatory (e.g., IL-10) cytokines from activated immune […]

Generalized Anxiety Disorder Linked to High IFN-γ and TNF-α but Low IL-10 Peripheral Levels

Generalized Anxiety Disorder Linked to High IFN-γ and TNF-α but Low IL-10 Peripheral Levels

A recent Brain, Behavior, and Immunity study provides perhaps the first evidence that Generalized Anxiety Disorder (GAD) is associated with a peripheral imbalance of pro- versus anti- inflammatory cytokines such as interferon (IFN)-γ, tumor necrosis factor (TNF)-α and interleukin (IL)-10. GAD, classified since the 1980s in the Diagnostic and Statistical Manual of Mental Disorder is […]

Glucocorticoid-Resistant IL-17- and IL-22-secreting CD4+ T Cells May Contribute to Increased Disease Activity in Multiple Sclerosis

Glucocorticoid-Resistant IL-17- and IL-22-secreting CD4+ T Cells May Contribute to Increased Disease Activity in Multiple Sclerosis

A recent study published in Immunology is perhaps the first to demonstrate a correlation between the production of interleukin (IL)-17 and IL-22, and its glucocorticoid resistance, and the number of active brain lesions in multiple sclerosis (MS). Increased active brain lesions were found in patients whose IL-17- and IL-22-producing T cells were more resistant to […]

First Evidence that Meningeal Interferon-γ Affects Neuronal Connectivity and Social Behavior

First Evidence that Meningeal Interferon-γ Affects Neuronal Connectivity and Social Behavior

A recent study published in Nature magazine links the meningeal immunity to the regulation of social behavior, implicating the meningeal interferon (IFN)-γ and its modulatory effects on the activity of brain cortex GABAergic neurons. Diseases such as autism spectrum disorder, frontotemporal dementia and schizophrenia are characterized by severe social and immune dysfunction. Little is known […]

Norepinephrine May Shift the IL-12/IL-23 Ratio of Dendritic Cells towards IL-23 Predominance thus Favoring Th17 Differentiation

Norepinephrine May Shift the IL-12/IL-23 Ratio of Dendritic Cells towards IL-23 Predominance thus Favoring Th17 Differentiation

A new study published in the January 15, 2016 issue of the Journal of Immunology indicates that in murine bone marrow–derived dendritic cells (DCs), norepinephrine, via stimulation of β2-adrenoceptors, is able to promote a shift in the IL-12p70/IL-23 cytokine ratio. Primary and secondary lymphoid organs receive a rich autonomic nervous system innervation, mainly by the […]

More Evidence that Norepinephrine and β3-Adrenoreceptors May Drive Melanoma Progression & Aggressiveness

More Evidence that Norepinephrine and β3-Adrenoreceptors May Drive Melanoma Progression & Aggressiveness

A report recently published in Oncotarget shows that the β3-adrenoreceptors are involved in melanoma aggressiveness, and that these receptors, expressed on several accessory cells, may orchestrate their function and thus, sustain melanoma progression. Recent research indicates that stress and stress mediators contribute to cancer development and/or progression. It appears that in this process a major […]

New Evidence that Peripheral Nerves Sense Infection and Drive IL-23 Production by Skin Dendritic Cells

New Evidence that Peripheral Nerves Sense Infection and Drive IL-23 Production by Skin Dendritic Cells

In a new study published in the journal Immunity, Sakeen Kashem and colleagues from the University of Minnesota, Minneapolis, MN, USA report that in the murine skin, IL-23, derived from CD301b+ DCs drives IL-17A production by γδ T cells, and this cytokine network is required to establish resistance to cutaneous candidiasis. Interleukin (IL)-23 is a […]

Low Cortisol and Glucocorticoid Signaling But High Levels of Inflammation: Risk Factors for Developing Depression in Patients with Coronary Heart Diseases

Low Cortisol and Glucocorticoid Signaling But High Levels of Inflammation: Risk Factors for Developing Depression in Patients with Coronary Heart Diseases

A new Brain Behavior and Immunity study indicates that depression in coronary heart disease (CHD) is associated with high levels of inflammation in the context of low cortisol output and glucocorticoid receptor (GR) resistance. Coronary heart disease (CHD) and major depressive disorders (MDD) are among the major causes of disability in developed countries. There is […]

Vasoactive Intestinal Peptide Inhibits Pathogenic Th17 Cells from Rheumatoid Arthritis Patients

Vasoactive Intestinal Peptide Inhibits Pathogenic Th17 Cells from Rheumatoid Arthritis Patients

A study published in the Journal of Leukocyte Biology indicates that in blood from rheumatoid arthritis (RA) patients, vasoactive intestinal peptide (VIP) shifts the activity of T cells towards a more T regulatory cell phenotype, and reduces the pathogenic profile of T helper (Th)17 cells. The vasoactive intestinal peptide (VIP) is well-known for its immunoregulatory […]

Evidence for Small Fiber Neuropathy in the Cornea of Fibromyalgia Patients

Evidence for Small Fiber Neuropathy in the Cornea of Fibromyalgia Patients

A new study published in Seminars in Arthritis & Rheumatism indicates that in patients with fibromyalgia the density of small nerve fibers in the cornea is reduced, supporting an evolving concept that fibromyalgia is a small fiber neuropathy. Fibromyalgia is also considered a stress-related syndrome that affects predominantly women. Recent research suggests that fibromyalgia is […]

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