News

A mix of news reporting on the latest developments in neuroendocrine-immunology & stress-immunity research

Teach the T Cells: Learned Immunosuppressive Placebo Responses in Renal Transplant Patients

Teach the T Cells: Learned Immunosuppressive Placebo Responses in Renal Transplant Patients

After organ transplantation or chronic inflammatory autoimmune diseases, patients depend on immunosuppressive medication for the rest of their lives, which can cause severe side effects. A recent study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) suggests that learned immunosuppressive placebo responses increased efficacy of immunosuppressive medication […]

PNIRS and GEBIN Conference in 2019 in Berlin, Germany

PNIRS and GEBIN Conference in 2019 in Berlin, Germany

The Psychoneuroimmunology Research Society (PNIRS) and the German Endocrine Brain Immune Network (GEBIN) will have their joint international meeting in Berlin, Germany, June 4-8, 2019. The meeting will take place at venues in/near the Charité, the famous University Hospital in Berlin. One location is the Lecture Hall Ruin (Hörsaalruine), which belongs to the Berlin Museum […]

First Evidence that Macrophages Modulate Heart Electrical Conduction System

First Evidence that Macrophages Modulate Heart Electrical Conduction System

In a recent Cell study, Maarten Hulsmans et al. report the presence of abundant resident macrophages in the heart atrioventricular (AV) node, and provide first evidence that these cells modulate the electrical conduction and activity of cardiomyocytes. This phenomenon may be related to the pathogenic electrical conduction in heart conditions such as atrial fibrillation and […]

A Sympathetic-Adrenal Neuroimmune Reflex Linked to the Immunosuppressive Effects of Spinal Cord Injury

A Sympathetic-Adrenal Neuroimmune Reflex Linked to the Immunosuppressive Effects of Spinal Cord Injury

A recent study published in Nature Neuroscience indicates that the increased susceptibility to life-threatening infections in spinal cord injury (SCI) patients may result from the disruption of the physiological interactions within a neuroendocrine reflex involving the sympathetic nervous system (SNS) and the adrenal glands. The control of the immune system by the peripheral autonomic nervous […]

Experimental Study Shows Link between Cerebrospinal Fluid IL-6 and Depressive Symptoms in Humans

Experimental Study Shows Link between Cerebrospinal Fluid IL-6 and Depressive Symptoms in Humans

A recent study published in Molecular Psychiatry suggests that the appearance of depressive symptoms in inflammatory conditions might be primarily linked to an increase in central IL-6 concentration. Inflammation is a physiological response to infection and tissue injury that involves the release of pro-inflammatory (e.g., TNF-α, IL-6) and anti-inflammatory (e.g., IL-10) cytokines from activated immune […]

Generalized Anxiety Disorder Linked to High IFN-γ and TNF-α but Low IL-10 Peripheral Levels

Generalized Anxiety Disorder Linked to High IFN-γ and TNF-α but Low IL-10 Peripheral Levels

A recent Brain, Behavior, and Immunity study provides perhaps the first evidence that Generalized Anxiety Disorder (GAD) is associated with a peripheral imbalance of pro- versus anti- inflammatory cytokines such as interferon (IFN)-γ, tumor necrosis factor (TNF)-α and interleukin (IL)-10. GAD, classified since the 1980s in the Diagnostic and Statistical Manual of Mental Disorder is […]

Stress and Catecholamines Up-Regulate Proinflammatory Cytokine Production and Neutrophil Infiltration in Experimental Colitis

Stress and Catecholamines Up-Regulate Proinflammatory Cytokine Production and Neutrophil Infiltration in Experimental Colitis

A recent Brain, Behavior and Immunity study indicates that psychological stress contributes to the exacerbation of the murine model of colitis by promoting the mobilization and entry of neutrophils in the colon. This appears to be achieved by the up-regulation of pro-inflammatory cytokine and chemokine production and STAT3 signaling, and involves β1/β2-adrenergic receptors activation. Inflammatory […]

Glucocorticoid-Resistant IL-17- and IL-22-secreting CD4+ T Cells May Contribute to Increased Disease Activity in Multiple Sclerosis

Glucocorticoid-Resistant IL-17- and IL-22-secreting CD4+ T Cells May Contribute to Increased Disease Activity in Multiple Sclerosis

A recent study published in Immunology is perhaps the first to demonstrate a correlation between the production of interleukin (IL)-17 and IL-22, and its glucocorticoid resistance, and the number of active brain lesions in multiple sclerosis (MS). Increased active brain lesions were found in patients whose IL-17- and IL-22-producing T cells were more resistant to […]

First Evidence that Meningeal Interferon-γ Affects Neuronal Connectivity and Social Behavior

First Evidence that Meningeal Interferon-γ Affects Neuronal Connectivity and Social Behavior

A recent study published in Nature magazine links the meningeal immunity to the regulation of social behavior, implicating the meningeal interferon (IFN)-γ and its modulatory effects on the activity of brain cortex GABAergic neurons. Diseases such as autism spectrum disorder, frontotemporal dementia and schizophrenia are characterized by severe social and immune dysfunction. Little is known […]

Chronic Stress Induces Shrinkage of Medial Amygdala Neurons in Mice: Recovery by the Fast-Acting Candidate Antidepressant Acetyl-L-Carnitine

Chronic Stress Induces Shrinkage of Medial Amygdala Neurons in Mice: Recovery by the Fast-Acting Candidate Antidepressant Acetyl-L-Carnitine

A recent study in Molecular Psychiatry provides new evidence that chronic stress generates structural remodelling of the brain amygdala, and particularly the shrinkage of medial amygdala neurons in mice. Chronic stress has been linked to cognitive impairment, but it is also known that stress modifies the neuronal architecture in several brain cognitive areas. However, little […]

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