Evolving Concepts

Featuring novel evolving concepts in the field

Major Depressive Disorder, Immunoregulation, Inflammation and Our Changing Microbial Environment

Major Depressive Disorder, Immunoregulation, Inflammation and Our Changing Microbial Environment

Evolving Concepts Urbanized societies are suffering an epidemic of chronic inflammatory disorders such as allergies, autoimmunity and inflammatory bowel disease. This is at least partly due to elimination from the hygienic modern concrete and tarmac environment of microorganisms and helminths with which man co-evolved. These organisms needed to be tolerated, and so were “entrusted” by […]

Evolutionary Medicine, Energy Regulation and the Pathogenesis of Systemic Chronic Inflammatory Diseases

Evolutionary Medicine, Energy Regulation and the Pathogenesis of Systemic Chronic Inflammatory Diseases

Evolving Concepts The general meaning of the systemic response in inflammatory diseases is not well understood. Nor do we know whether the systemic response has any unfavorable role when inflammatory diseases become chronic. We call chronic inflammatory diseases (CIDs) “systemic in nature”, but the significance of these systemic signs and symptoms is not known. In […]

Beta Blockers Hold Substantial Potential for Therapeutical Interventions in Cancer

Beta Blockers Hold Substantial Potential for Therapeutical Interventions in Cancer

Evolving Concepts Recently, more than 10 studies [see References 1-11], published in the last 3-4 years indicate the presence of high intratumoral concentrations of catecholamines and that these neurohormonal mediators affect key components of tumor biology such as tumor growth, angiogenesis, and migration or invasion [for details see References 12-13]. These studies suggest that blocking […]

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