Blogs

Short news & blogs covering the advance in neuroendocrine-immunology, neuroscience & immunology

Chronic Urticaria Linked to a Th2/Th17 Shift in Skin Lesions

Chronic Urticaria Linked to a Th2/Th17 Shift in Skin Lesions

A new study by Andrea Moy, Mandakolathur Murali and Rosalynn Nazarian, published in the Journal of Cutaneous Pathology, indicates that in the chronic urticaria skin lesions the immune response is characterized by a Th2/Th17 shift. Chronic urticaria (hives) is a condition where an itchy rash persists on and off for six weeks or more. The […]

Interleukin-33 Reverses Cognitive Deficits in Alzheimer’s Mouse Model Showing Promise as a Therapeutic Target

Interleukin-33 Reverses Cognitive Deficits in Alzheimer’s Mouse Model Showing Promise as a Therapeutic Target

A new study published in the Proceedings of the National Academy of Sciences USA (PNAS) indicates that interleukin-33 (IL-33) is able to improve memory deficits and reduce the accumulation of β-amyloid in APP/PS1 mice that exhibit Alzheimer’s disease (AD)-like pathologies. IL-33 is a member of the IL-1 cytokine family and is considered an ‘alarm’ molecule […]

Periodontitis Linked To Cognitive Decline in Alzheimer’s Disease

Periodontitis Linked To Cognitive Decline in Alzheimer’s Disease

A new study published in the online journal PLoS One suggests that individuals with poor dental health and periodontitis may have marked increase in cognitive decline related to Alzheimer’s disease (AD). This is perhaps the first longitudinal study examining the correlation between poor dental health and cognitive outcomes. Research has shown that periodontal (gum) disease may […]

Th17 Cells and Lymphotoxin Promote Tertiary Lymphoid Tissues Formation and Neuroinflammation

Th17 Cells and Lymphotoxin Promote Tertiary Lymphoid Tissues Formation and Neuroinflammation

According to a recent study published in Immunity, T helper (Th)17 cells initiate tertiary lymphoid tissues (TLTs) development in the meninges and propagate brain neuroinflammation. Tertiary lymphoid tissues or tertiary lymphoid organs (TLOs) represent accumulations of lymphoid cells at ectopic sites (in contrast to most lymphoid tissues developing before birth) usually triggered by chronic inflammation. […]

Interleukin-35 Restrains Lymphocytic Infiltration and T Cell-Dependent Anti-Tumor Immunity

Interleukin-35 Restrains Lymphocytic Infiltration and T Cell-Dependent Anti-Tumor Immunity

A new study published in the journal Immunity indicates that interleukin (IL)-35 inhibits the recruitment of effector anti-tumor T cells and suppresses their function in the tumor microenvironment. IL-35 belongs to the IL-12 family of cytokines. It is a dimeric protein composed of two subunits – p35 and EBI3, which are shared with other IL-12 […]

Inhibitors of RORγt Targeting Th17 Cells May Hold Promising Therapeutic Potential in Inflammation & Autoimmunity

Inhibitors of RORγt Targeting Th17 Cells May Hold Promising Therapeutic Potential in Inflammation & Autoimmunity

Recently, several RORγt inhibitors have been identified that effectively restrict the function and differentiation of pro-inflammatory T helper (Th)17 cells. The transcription factor RORγt belongs to the nuclear receptor superfamily – consisting of 48 members that serve as ligand-activated transcription factors translating extracellular or intracellular signals into a transcriptional response. RORγt is the immune cell-specific […]

New Evidence that Stress May Increase the Risk of Developing Dementia and Alzheimer’s: the Einstein Aging Study

New Evidence that Stress May Increase the Risk of Developing Dementia and Alzheimer’s: the Einstein Aging Study

According to a recent report published in the journal Alzheimer Disease & Associated Disorders stress may increase up to 30% the risk of developing amnestic mild cognitive impairment (aMCI) or dementia. Mild cognitive impairment is a significant risk factor for the development of dementia and Alzheimer’s disease. Moreover, among all MCI subtypes, patients with amnestic […]

Stress May Contribute To Male Infertility by Affecting Sperm Concentration, Motility and Morphology

Stress May Contribute To Male Infertility by Affecting Sperm Concentration, Motility and Morphology

A recent study, published in the journal Fertility and Sterility, indicates that perceived stress and stressful life events, but not work-related stress, are associated with semen quality such as sperm concentration, motility and morphology. According to a recent review article in Nature Reviews Urology a close relationship seems to exist between the testes and the […]

Th17 and Th22 Cells May Contribute To the Pathogenesis of Guillain-Barré Syndrome

Th17 and Th22 Cells May Contribute To the Pathogenesis of Guillain-Barré Syndrome

A study by Shujuan Li and colleagues from the Jilin University, Changchun, China, suggests that Th17 and Th22 cells might be involved in the onset and development of Guillain-Barré Syndrome. Guillain-Barré syndrome (GBS), described in 1916 by George Guillain, Jean-Alexandre Barré, and André Strohl, is an acute inflammatory immune-mediated polyradiculoneuropathy presenting typically with tingling, progressive […]

Personality Traits like Extraversion and Conscientiousness Linked to Pro-Inflammatory Genes Expression

Personality Traits like Extraversion and Conscientiousness Linked to Pro-Inflammatory Genes Expression

A study published in the journal Psychoneuroendocrinology demonstrates that leukocyte gene expression correlates with two major dimensions of human personality, extraversion and conscientiousness. A recent study in nonhuman primates provides new insights into the neuroanatomical basis of personality, showing that personality traits are linked to the anatomy of specific brain structures such as the anterior […]