Brain Immune System Signal Molecules in Protection from Aerobic and Anaerobic Infections (Advances in Neurobiology)
Proline-rich polypeptides – in particular (PRP-1) galarmin and its structural analogues – are, when isolated from the neurosecretory granules of neurohypophysis of humans and animals, a new type of hypothalamic peptides. They work against aerobic, anaerobic, gram-positive, and gram-negative microorganisms in vivo, and do not have etiotropic properties. They are unique and capable substitutes to antibiotics, and, moreover, may be effective against strains, such as MRSA, that develop resistance to antibiotics. Galarmin, a component of the brain neuroendocrine system produced by the neurosecretory cells of hypothalamus, possesses immunomodulative, neuroprotective, antioxidant, antitumorigenic and hematopoietic properties. Moreover, galarmin and its structural analogues are powerful anti-inflammatory compounds.
In addition to presenting a full overview of the neuroimmune system, it emphasizes the antibacterial, neuroprotective, and neuroregenerative properties of proline-rich polypeptides. It investigates the mechanism of galarmin’s action during different infectious processes, where it targets such dangerous pathogens as Bacillus anthracis, Clostridium perfringens, Mycobacterium tuberculosis, and Methycillin resistant Staphylococcus aureus. This research is important from both a theoretical and a clinical point of view, creating new prospects for the modern pharmaceutical industry and neuroendocrine, neuroimmunological sciences.
Dr. Galoyan is a pioneer of the specialized field of neuroimmunology. During his 45-year long career, he has discovered a neuroendocrine immune system of the brain and identified a new type of brain cytokines: proline-rich polypeptides. The most important of these, PRP-1 (galarmin) has been shown to possess antibacterial properties and protect from certain neurotoxins.
Some chapters of this book are listed below:
- Brain Immune System Signal Molecules in Protection from Aerobic and Anaerobic Infections
- Antibacterial and Antiviral Activity of PRP-1 (Galarmin) and Some Immunological Mechanisms of its Action
- Treatment and Prophylaxis of Anthrax by Galarmin: Receptor Tyrosine Kinases is a Target of Galarmin
- Prophylaxis and Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection with Proline-Rich Polypeptides Galarmin and Its Structural Analogues in an Experimental Murine Model
- Brain–Bone Marrow Neurohumoral Axis: Galarmin Controls Differentiation, Proliferation and Mobilization of Bone Marrow Progenitor cells
Series: Advances in Neurobiology (Book 6); Paperback: 200 pages; Publisher: Springer; 2012 edition (July 17, 2014).