The Brain Immune Axis and Substance Abuse

The Brain Immune Axis and Substance AbuseThe Brain Immune Axis and Substance Abuse, published by Springer and edited by BM Sharp, T. Eisenstein, JJ Madden and Friedman, H., represents the proceedings of the symposium on the Brain Immune Axis and Substance Abuse held in Palm Beach, FL in June 1994.

The book covers 31 chapters addressing the effect of drugs of abuse on the brain immune axis, presenting new data on molecular and cellular immunomodulation of drugs of abuse, particularly opiates and cannabanoids.

Only in the last decade have investigators begun to describe the effects of drugs of abuse on the immune system and on infections among individuals who abuse drugs are also of recent vintage. Thus, the involvement of the neuroendocrine system in the interactions of drugs of abuse and the immune system has only recently been appreciated.

In addition, it has been recognized that direct neural inputs impact immune function. Given the complexity of these interactions, characterization of biologically significant phenomena and elucidation of their mechanisms of action often requires a multidisciplinary approach.

This meeting, on which the chapters in this book are based, brought together scientists from an array of biomedical disciplines whose work is focused on the effects of drugs of abuse on the neuro-endocrine immune axis.

The meeting was unique in focusing on the brain-immune axis from the viewpoint of drugs of abuse rather than either immunity itself or the brain itself. Presentations addressed the direct effects of drugs of abuse on various components of the immune system, as well as those mediated indirectly by the central nervous system and the neuroendocrine system.

Few selected chapters are listed below:

  • Identification of Opioid Receptors in the Immune System Using a Novel Combination of Selective Opioid Ligands and Indirect Phycoerythrin Immunofluorescence
  • Delta Opioid Agonists Inhibit Proliferation of Highlypurified Murine CD4+ and CD8+ T-Cells
  • Mitogenic Activation of Human T Lymphocytes Induces a High Affinity Morphine Binding Site
  • Morphine-Induced Suppression of Thymocyte Proliferation is Mediated by Inhibition of IL-2 Synthesis
  • Marijuana, Receptors and Immunomodulation
  • Mouse Strain Differences in in vivo and in vitro Immunosuppressive Effects of Opioids
  • Mechanisms Whereby Macrophage-Derived Nitric Oxide is Involved in Morphine-Induced Immunomodulation
  • Effects of Central Administration of Morphine on Immune Status in Lewis and Wistar Rats
  • Adjuvant Effects on Morphine-Induced Suppression of Immune Responses to MN rgp120/HIV-1 in Mice
  • Role of Immune Processes in Peripheral Opioid Analgesia
  • Chronic Treatment with Morphine and Ethanol, But Not Cocaine, Attenuates IL-1β Activation of FOS Expression in the Rat Hypothalamic Paraventricular Nucleus

The book targets neuroscientists, immunologists, pharmacologists, microbiologists, and healthcare professionals caring for individuals with addictive and infectious disorders.

Hardcover: 356 pages; Publisher: Springer; 1 edition (May 31, 1995)

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