An Introduction to the Study of Experimental Medicine

An Introduction to the Study of Experimental Medicine, a masterpiece and a classic book which is still read, is written by Claude Bernard, the father of modern physiology and experimental medicine. In 1865, forced by sickness to abandon his teaching and research activities, Bernard wrote this book, establishing as general principles his thoughts about experimentation […]

Raloxifene and Two New Selective Estrogen Receptor Modulators (SERMs) Inducing M2-Macrophage Shift and High IL-10 and IL-1Ra Production

Raloxifene and Two New Selective Estrogen Receptor Modulators (SERMs) Inducing M2-Macrophage Shift and High IL-10 and IL-1Ra Production

A new study published in the journal Inflammation indicates that in myeloid cells raloxifene and two new selective estrogen receptor modulators (SERMs) are able to induce a shift to M2-macrophage anti-inflammatory phenotype, characterized by high production of interleukin (IL)-10 and IL-1 receptor antagonist (IL-1Ra). Estrogens exert pleiotropic immuno-modulatory and immuno-regulatory effects, contributing to the sexual […]

Evidence that Microglia in Fibromyalgia is Hypersensitive and Overproducing TNF-α

Evidence that Microglia in Fibromyalgia is Hypersensitive and Overproducing TNF-α

The first study suggesting abnormal activation of microglia in fibromyalgia, published in Scientific Reports, indicates that microglia in patients with fibromyalgia are probably hypersensitive and overproducing tumor necrosis factor (TNF)-α in response to the neurotransmitter ATP. Both dysautonomia and cytokine abnormalities have been implicated in the pathogenesis of fibromyalgia. fMRI studies in humans suggests a […]

Norepinephrine through β2-adrenoceptor activation down-regulates pro-inflammatory pathogenic Th17 cells in a rodent model of rheumatoid arthritis

Norepinephrine through β2-adrenoceptor activation down-regulates pro-inflammatory pathogenic Th17 cells in a rodent model of rheumatoid arthritis

What’s Hot A recent study in Medical Science Monitor indicates that norepinephrine (noradrenaline), the major sympathetic nervous system neurotransmitter, through stimulation of β2-adrenoceptors (AR) is able to suppress the highly pathogenic T helper 17 (Th17) cells and exert anti-inflammatory effects in a mouse model of arthritis. In 1986 Mosman et al. discovered the Th1 (mostly […]

2017 in Review: New Advances in Neuroendocrine Immunology

2017 in Review: New Advances in Neuroendocrine Immunology

Editorial In 2017, we witnessed further rapid growth in the vast interdisciplinary area of neuroendocrine immunology. It became a tradition to reflect on the new significant developments and conceptual trends in the field that were presented at BrainImmune. We will retrace some of our commentaries, revisiting the studies on BrainImmune we believe are illustrative, stimulating […]

First Evidence that Catecholamines Inhibit IL-27 Production by Antigen Presenting Cells

First Evidence that Catecholamines Inhibit IL-27 Production by Antigen Presenting Cells

A recent J. Immunology study provides perhaps the first evidence that catecholamines such as norepinephrine and epinephrine suppress the production of interleukin-27 (IL-27) via the activation of β2-adrenoceptors, and by mechanisms involving IL-10 and the JNK signaling pathway. Homeostasis within the immune system is largely dependent on cytokines, the ‘hormones’ of the immune system that […]

The Evolving Link between Social Media Addiction and Depression in Young Adults

The Evolving Link between Social Media Addiction and Depression in Young Adults

Recently, in the journal Pediatrics, Elizabeth Hoge, MD, David Bickham, PhD and Joanne Cantor, PhD outlined recent evidence that the social media addiction breeds and catalyzes anxiety and depression in children. In the US some teens spend about nine hours daily using media, whereas 24 percent of teenagers are online constantly, and 59% of children […]

Cognitive Decline and Alzheimer’s Linked to Low Systemic REST Levels and Deficient Stress Protection of the Aging Brain

Cognitive Decline and Alzheimer’s Linked to Low Systemic REST Levels and Deficient Stress Protection of the Aging Brain

A study published in Translational Psychiatry indicates that low systemic (plasma) levels of the repressor element 1-silencing transcription (REST) factor represent a candidate biomarker of cognitive decline and Alzheimer’s disease (AD). The study also suggests that low systemic REST levels may be associated with a poor brain stress protection during aging. Recent research suggests that […]

The Chemokines CX3CL1 and IL-8 May Be Implicated in the Pathogenesis of Fibromyalgia

The Chemokines CX3CL1 and IL-8 May Be Implicated in the Pathogenesis of Fibromyalgia

A new study published in the Journal of Pain Research reports the presence of high levels of the chemokines CX3CL1 (also known as fractalkine) and interleukin-8 (IL-8) in fibromyalgia (FM) patients. Fibromyalgia is the “current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified”. Typical symptoms includes chronic widespread pain, […]

Neuroendocrine-Immunology Progress and Development Stories: 2016 in Review

Neuroendocrine-Immunology Progress and Development Stories: 2016 in Review

Editorial Neuroendocrine-immunology has achieved substantial progress and growth over the last year. As the BrainImmune mission is to promote the advancement of this research field, it is becoming a tradition to recapitulate the latest developments in this relatively new interdisciplinary area that bridges neurosciences and immunology. Note that this is not a complete list, but […]

Page 1 of 16123Next ›Last »