The Evolving Link between Social Media Addiction and Depression in Young Adults

The Evolving Link between Social Media Addiction and Depression in Young Adults

Recently, in the journal Pediatrics, Elizabeth Hoge, MD, David Bickham, PhD and Joanne Cantor, PhD outlined recent evidence that the social media addiction breeds and catalyzes anxiety and depression in children. In the US some teens spend about nine hours daily using media, whereas 24 percent of teenagers are online constantly, and 59% of children […]

Cognitive Decline and Alzheimer’s Linked to Low Systemic REST Levels and Deficient Stress Protection of the Aging Brain

Cognitive Decline and Alzheimer’s Linked to Low Systemic REST Levels and Deficient Stress Protection of the Aging Brain

A study published in Translational Psychiatry indicates that low systemic (plasma) levels of the repressor element 1-silencing transcription (REST) factor represent a candidate biomarker of cognitive decline and Alzheimer’s disease (AD). The study also suggests that low systemic REST levels may be associated with a poor brain stress protection during aging. Recent research suggests that […]

The Chemokines CX3CL1 and IL-8 May Be Implicated in the Pathogenesis of Fibromyalgia

The Chemokines CX3CL1 and IL-8 May Be Implicated in the Pathogenesis of Fibromyalgia

A new study published in the Journal of Pain Research reports the presence of high levels of the chemokines CX3CL1 (also known as fractalkine) and interleukin-8 (IL-8) in fibromyalgia (FM) patients. Fibromyalgia is the “current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified”. Typical symptoms includes chronic widespread pain, […]

Neuroendocrine-Immunology Progress and Development Stories: 2016 in Review

Neuroendocrine-Immunology Progress and Development Stories: 2016 in Review

Editorial Neuroendocrine-immunology has achieved substantial progress and growth over the last year. As the BrainImmune mission is to promote the advancement of this research field, it is becoming a tradition to recapitulate the latest developments in this relatively new interdisciplinary area that bridges neurosciences and immunology. Note that this is not a complete list, but […]

Antibiotics through Effects on the Microbiota-Gut-Brain Axis and Inflammatory Monocytes May Reshape Brain Hippocampal Neurogenesis

Antibiotics through Effects on the Microbiota-Gut-Brain Axis and Inflammatory Monocytes May Reshape Brain Hippocampal Neurogenesis

A new Cell Reports study indicates that ‘inflammatory’ monocytes may represent the missing ‘pathogenic link’ between the antibiotics’ effects on gut microbiota, and the subsequent changes in the brain hippocampal neurogenesis and plasticity. Recent research suggests that antibiotics may exert some of their unsolicited side effects through effects on the gut-brain axis. Soon after birth, […]

Gut and Gingival Bacteria: Game Changers or Innocent Bystanders in Rheumatoid Arthritis?

Gut and Gingival Bacteria: Game Changers or Innocent Bystanders in Rheumatoid Arthritis?

Several publications in the last 2-3 years brought more interest in the link between gut and gingival bacteria or microbiota, and human health and diseases, and particularly their possible game changer role in the pathogenesis of rheumatoid arthritis. The human gastrointestinal tract comprises approximately 1014 bacterial microbes and amounts to a biomass of approximately 2 […]

IL-35 Contributing to Immune Tolerance in Normal Pregnancy

IL-35 Contributing to Immune Tolerance in Normal Pregnancy

A study published in PLoS One indicates that normal pregnancy is associated with increased levels of interleukin (IL)-35, whereas recurrent spontaneous abortions are linked to low levels of this cytokine, suggesting the involvement of IL-35 in the maintenance of immune tolerance during pregnancy. IL-35, identified in 2007 is a major immunosuppressive and anti-inflammatory cytokine along […]

Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma

Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma

A recent Journal of Translational Medicine study indicates that interleukin (IL)-33 is produced by bronchial smooth muscle cells (BSMCs) upon rhinovirus (RV) infection and activation of TLR3, and that this response is associated and/or mediated by ATP released by viral-stimulated BSMCs. IL-33 is a cytokine constitutively expressed in epithelial barrier tissues, and was originally described […]

The Therapeutic Potential of Secukinumab in Rheumatic Diseases

The Therapeutic Potential of Secukinumab in Rheumatic Diseases

A review by Marije Koenders in Drug Design, Development and Therapy outlines some major features and characteristics of the new biological Secukinumab, which blocks the actions of interleukin 17A (IL-17), and explores its development, therapeutic potential and use in several rheumatic diseases. IL-17 provides protection against extracellular bacterial and fungal infections. However, IL-17 and Th17 […]

Job Burnout Reaching an Unprecedented Level and Half of US Physicians Experiencing Professional Burnout

Job Burnout Reaching an Unprecedented Level and Half of US Physicians Experiencing Professional Burnout

According to a recent Fast Company article, job burnout, in general, is reaching an unprecedented level, and as per a January 2017  Mayo Clinic Proceedings report “50% of US physicians are experiencing professional burnout”. Burnout syndrome is mostly a work-related condition and the subject’s response to chronic work-related stress. According to the classical definition, this […]

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