Inflammation and Immunity in Depression: Basic Science and Clinical Applications

Inflammation and Immunity in Depression is edited by Bernhard Baune and published by Academic Press. Evidence accumulated in the last 2-3 decades indicates that inflammation is an important pathogenic factor in depression. Also, some forms of depression are related to sustained increases in circulating proinflammatory cytokines. Inflammation and Immunity in Depression: Basic Science and Clinical […]

Neuro-Immuno-Gastroenterology

Neuro-Immuno-Gastroenterology is edited by Cris S. Constantinescu, Rāzvan I. Arsenescu and Violeta Arsenescu, and published by Springer. This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system […]

Insights to Neuroimmune Biology 2nd Edition

Insights to Neuroimmune Biology is edited by Istvan Berczi, and published by Elsevier. This book discusses the systemic regulatory network, coordination, organization, and interpretation of the rapidly accumulating knowledge on the topic of neuroimmune biology, with an ultimate goal of helping readers understand the function of higher organisms, including man, in their entire complexity. This […]

Neuroimmunity: A New Science That Will Revolutionize How We Keep Our Brains Healthy and Young

Neuroimmunity: A New Science That Will Revolutionize How We Keep Our Brains Healthy and Young is authored by Michal Schwartz and Olle Lindvall, and published by Yale University Press. In the past, the brain was considered an autonomous organ, self-contained and completely separate from the body’s immune system. But over the past twenty years, neuroimmunologist […]

2017 in Review: New Advances in Neuroendocrine Immunology

2017 in Review: New Advances in Neuroendocrine Immunology

Editorial In 2017, we witnessed further rapid growth in the vast interdisciplinary area of neuroendocrine immunology. It became a tradition to reflect on the new significant developments and conceptual trends in the field that were presented at BrainImmune. We will retrace some of our commentaries, revisiting the studies on BrainImmune we believe are illustrative, stimulating […]

First Evidence that Catecholamines Inhibit IL-27 Production by Antigen Presenting Cells

First Evidence that Catecholamines Inhibit IL-27 Production by Antigen Presenting Cells

A recent J. Immunology study provides perhaps the first evidence that catecholamines such as norepinephrine and epinephrine suppress the production of interleukin-27 (IL-27) via the activation of β2-adrenoceptors, and by mechanisms involving IL-10 and the JNK signaling pathway. Homeostasis within the immune system is largely dependent on cytokines, the ‘hormones’ of the immune system that […]

First Evidence that Macrophages Modulate Heart Electrical Conduction System

First Evidence that Macrophages Modulate Heart Electrical Conduction System

In a recent Cell study, Maarten Hulsmans et al. report the presence of abundant resident macrophages in the heart atrioventricular (AV) node, and provide first evidence that these cells modulate the electrical conduction and activity of cardiomyocytes. This phenomenon may be related to the pathogenic electrical conduction in heart conditions such as atrial fibrillation and […]

A Sympathetic-Adrenal Neuroimmune Reflex Linked to the Immunosuppressive Effects of Spinal Cord Injury

A Sympathetic-Adrenal Neuroimmune Reflex Linked to the Immunosuppressive Effects of Spinal Cord Injury

A recent study published in Nature Neuroscience indicates that the increased susceptibility to life-threatening infections in spinal cord injury (SCI) patients may result from the disruption of the physiological interactions within a neuroendocrine reflex involving the sympathetic nervous system (SNS) and the adrenal glands. The control of the immune system by the peripheral autonomic nervous […]

Afferent Vagus Nerve Stimulation Activates Brain Locus Coeruleus and Improves Experimental Joint Inflammation

Afferent Vagus Nerve Stimulation Activates Brain Locus Coeruleus and Improves Experimental Joint Inflammation

A recent study published in the Brain, Behavior, and Immunity journal indicates, for the first time, that stimulation of vagal afferents or specific brain areas can modulate joint inflammation. This new central pathway involves sympathetic nervous system activation and local stimulation of synovial β-adrenoceptors. Vagus nerve stimulation (VNS) is a well-known procedure that limits inflammation and […]

The Central Inflammatory Reflex: Afferent Vagal and Central Brain Stimulations Control Experimental Arthritis

The Central Inflammatory Reflex: Afferent Vagal and Central Brain Stimulations Control Experimental Arthritis

PhD THESIS SYNOPSIS Inflammation is a protective and complex biological response to harmful stimuli, such as infection and tissue damage, that involves cell infiltration and production of inflammatory cytokines. Rheumatoid Arthritis (RA) is the most common type of inflammatory autoimmune disease affecting over 1.5 million adult Americans. It is characterized by chronic inflammation of synovial […]

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