Neuroimmune pharmacology 2nd edition

Neuroimmune pharmacology is a relatively new discipline, however well-grounded on interdisciplinary basic and translational research in pharmacology, immunology and neuroscience, aiming at the therapeutic exploitation of the rapidly growing knowledge about physiology and pathology of nervous system-immune system interconnections. The Society on Neuroimmune Pharmacology was founded in1993, while the first issue of the Journal of […]

Post Doc Research Fellow Position: Peripheral Immunity in Aging & Parkinson’s

Post Doc Research Fellow Position: Peripheral Immunity in Aging & Parkinson’s

PERIPHERAL IMMUNITY in AGING & PARKINSON’S DISEASE: OPEN CALL for 1 Post Doc Research Fellow position (12+12 months) The Center for Research in Medical Pharmacology, University of Insubria (Varese, Italy) works on the role of peripheral immunity in aging and Parkinson’s disease with particular regard to T cells as biomarkers of immunoaging and their relationship […]

β2-Adrenergic Agonists for Parkinson’s Disease: Repurposing Drugs at the Crossroad of the Brain and the Immune System

β2-Adrenergic Agonists for Parkinson’s Disease: Repurposing Drugs at the Crossroad of the Brain and the Immune System

Commentary On the study by Mittal S, Science, 2017; 357(6354):891-898. doi: 10.1126/science.aaf3934 β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease Parkinson’s disease (PD) affects 0.1-0.2% of the general population with increasing prevalence with age, and up to 1% in individuals above 60 years of age, resulting in an estimated 7 […]

Beta-Adrenoceptors and Tumor Development: Novel Concepts and Clinical Implications

Beta-Adrenoceptors and Tumor Development: Novel Concepts and Clinical Implications

Evolving Concepts Over the last 3 decades, an increasing body of evidence suggests that catecholamine-dependent signalling may represent a major link between chronic stress and tumor progression. Studies addressing the relationship between stress-activated pathways and cancer progression suggest that stress-induced production of adrenaline and noradrenaline, besides affecting the anti-tumor immune response also displays direct tumor-promoting […]

Endogenous Catecholamines in Immune Cells: Discovery, Functions And Clinical Potential as Therapeutic Targets

Endogenous Catecholamines in Immune Cells: Discovery, Functions And Clinical Potential as Therapeutic Targets

Overview article The catecholamines dopamine, noradrenaline and adrenaline are well established neurotransmitters and neurohormones. Sympathoadrenergic pathways are pivotal to the communication between the nervous system and the immune system, and the role of dopaminergic pathways in the modulation of immune response is being increasingly unveiled. However, over the last two decades, evidence has accumulated regarding […]