BrainImmune: Trends in Neuroendocrine Immunology

New Evidence for Key Factors that Drive COVID-19 Severity

Commentary On: Viral and host factors related to the clinical outcome of COVID-19, by Zhang et al., Nature, 2020 Jul;583(7816):437-440. doi: 10.1038/s41586-020-2355-0. The COVID-19 outbreak was first identified in Wuhan, China. Despite the causal agent being closely related to a bat coronavirus (RaTG13), several questions…

Stress, Dyshomeostasis and COVID-19 Mortality: A Big Picture View

Commentary Note that the information contained herein is NOT instructional for medical diagnosis or treatment, see the BrainImmune DISCLAIMER at the end of this article! The pandemic viral illness COVID-19 is especially life-threatening in the elderly and in people with any of a variety of

β2-Adrenoceptor-Mediated Upregulation of IL-17 May Contribute to Pulmonary Immunopathology in COVID-19: Does Blockade of IL-17 and β-Adrenergic Effects Hold a Therapeutic Potential?

Research Hypothesis Note that this is a research hypothesis – the information contained herein is NOT instructional for medical diagnosis or treatment, see the BrainImmune DISCLAIMER at the end of this article! It has been reported that nucleotide-binding oligomerization domain 2 (NOD2) can also function

Sympathetic Nervous System Dysfunction in Rheumatoid Arthritis: Brief Overview

Rheumatoid arthritis (RA) is an autoimmune condition characterized by chronic inflammation occurring locally within the synovial joints and systemically. Accumulating evidence supports an important role of the sympathetic nervous system in the pathophysiology of RA, both as a cause and consequence of inflammation. Acute sympathetic

Parkinson’s Disease: Peripheral Immunity Links Neurodegeneration and the Intestinal Microbiota

Commentary By Marco Cosentino, Cristoforo Comi and Franca Marino On the study by Matheoud D et al., Nature, 2019; 571(7766):565-569; Doi: 10.1038/s41586-019-1405-y, Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1-/- mice. Parkinson’s disease (PD) is a chronic neurodegenerative disease affecting 7 to 10 million people…

The Emerging Role of Neuro-Immune Synapses and the Immunological Homunculus in the Context of the Systematic Lymphoid Organs Innervation

Evolving concept By Clemens Wülfing, Fenja Amrei Schuran, Inga Hölge, Julia Urban, Jasmin Oehlmann and Hauke Simon Günther Nearly all body tissues are connected to the central nervous system through the axonal terminals of neurons. But with regard to lymphoid organs, this direct innervation, its…

Learned Immunosuppressive Placebo & Arthritis Experimental Study Shows that Le…
Pain neurons & S. pyogenes infection Neural Suppression Neutralizes F…
Perispinal Etanercept & Stroke Treatment Australian Government Advances S…
Growth Hormone & Pneumococcal Disease Are children with growth hormone…

New Evidence for Key Factors that Drive COVID-19 Severity

Stress, Dyshomeostasis and COVID-19 Mortality: A Big Picture View

β2-Adrenoceptor-Mediated Upregulation of IL-17 May Contribute to Pulmonary Immunopathology in COVID-19: Does Blockade of IL-17 and β-Adrenergic Effects Hold a Therapeutic Potential?

Sympathetic Nervous System Dysfunction in Rheumatoid Arthritis: Brief Overview

Parkinson’s Disease: Peripheral Immunity Links Neurodegeneration and the Intestinal Microbiota

The Emerging Role of Neuro-Immune Synapses and the Immunological Homunculus in the Context of the Systematic Lymphoid Organs Innervation

Microglia: gatekeepers for neuropathic pain

Neuroendocrine Immune Implications in Rheumatoid Arthritis and Polymyalgia Rheumatica: Past and Present Unresolved Issues and Optimising Glucocorticoid Treatment

New Evidence for Key Factors that Drive COVID-19 Severity

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Disruption of Brain TNF Homeosta…

The American Institute of Stress

GEBIN, the German-Endocrine-Brai…

The European Commission Approves Remdesivir for the Treatment of Severe Cases of COVID-19

Acid Sensing By Sensory Neurons in Infla…

Endogenous Catecholamines in Immune Cell…

Sex Steroids Hormones and Autoimmune Dis…

Neuroendocrine-Immune Interactions in Lu…

Blogs & Short News

WHO Director – “a ‘silver (magic) bullet’ for COVID-19 is most likely elusive”

Evidence that Microglia in Fibromyalgia is Hypersensitive and Overproducing TNF-α

Cognitive Decline and Alzheimer’s Linked to Low Systemic REST Levels and Deficient Stress Protection of the Aging Brain

The Chemokines CX3CL1 and IL-8 May Be Implicated in the Pathogenesis of Fibromyalgia

IL-35 Contributing to Immune Tolerance in Normal Pregnancy

Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma

The Therapeutic Potential of Secukinumab in Rheumatic Diseases

Job Burnout Reaching an Unprecedented Level and Half of US Physicians Experiencing Professional Burnout

The BrainImmune Short Video about Stress and the Stress-Immune Interactions

Stress & Organ Specific Autoimmunity: A Complex Interrelationship

Donna Jackson Nakazawa and Her New Book, THE ANGEL AND THE ASSASSIN: The Tiny Brain Cell that Changed the Course of Medicine

BrainImmune and Brief History of Neuroendocrine Immunology and Stress-Immune Interactions

Bridging Neurosciences and Immunology – An Overview

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