BrainImmune: Brain-Immune Interactions Resource

Neuroendocrine Immune Implications in Rheumatoid Arthritis and Polymyalgia Rheumatica: Past and Present Unresolved Issues and Optimising Glucocorticoid Treatment

Editorial Introduction and background The dramatic effects of cortisone and pituitary adrenocortical hormone therapy on rheumatoid arthritis (RA) were discovered almost seven decades ago (1) and even longer for the significant disease amelioration during pregnancy as reported by Hench in 1938 (2). However, major questions

Microglia: gatekeepers for neuropathic pain

Evolving Concepts Introduction Where acute pain protects an individual from further damage, chronic pain serves no adaptive purpose. Approximately 1 in 5 people suffer from chronic pain, which exacts a substantial toll on the both the individual and on national economies [1–3]. Chronic pain can

The Cross-talk between the Dopaminergic System and Innate Immunity: An Evolving Concept

Evolving Concept Dopamine (DA) is a well-known neurotransmitter in the central nervous system (CNS). An increasing body of evidence, however, indicates that DA is also an important communication mediator at the neural-immune interface [1-3]. Most research and studies to date have put the emphasis on

An Evolving Concept: The Pathologic Level of Brain TNF is a Therapeutic Target for Chronic Pain Treatment

Evolving Concept Chronic pain is a serious healthcare dilemma with many treatment options available, such as antidepressants, non-steroidal anti-inflammatory drugs, opioids, and anticonvulsants; nevertheless, chronic pain presently is not appropriately managed. A fundamental reason for the lack of effective treatment is that none of these

The selfishness of the brain and immune systems provoke energy deficiency in aging and chronic inflammation

Evolving Concepts “I feel exhausted with mental stress and with systemic inflammation, but why?” In recent publications [1-5], in highly active chronic inflammatory diseases, I demonstrated how energy shortage due to an active and selfish immune system can stimulate a plethora of common signs and

Brain Superautoantigens: Connections between Immune and Neural Repertoires

Opinion Article Introduction Although human cells express a quasi-infinite number of potential autoantigens, only a limited range of the human “self” antigen library is actually targeted by pathological autoimmunity. Accordingly, the clinical expression of human autoimmunity is essentially restricted to relatively few stereotyped disorders including

Pain neurons & S. pyogenes infection Neural Suppression Neutralizes F…
Perispinal Etanercept & Stroke Treatment Australian Government Advances S…
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Teach the T Cells Teach the T Cells: Learned Immun…
PNIRS & GEBIN Conference PNIRS and GEBIN Conference in 20…

Evolving Concepts

Understanding the Role of Inflammation in Fatigue Requires Multidimensional Assessments

Evolving concepts Introduction “I am tired”. What…

Editorials

2017 in Review: New Advances in Neuroendocrine Immunology

Editorial In 2017, we witnessed further rapid growth in the vast interdisciplinary…

What's hot

Raloxifene and Two New Selective Estrogen Receptor Modulators (SERMs) Inducing M2-Macrophage Shift and High IL-10 and IL-1Ra Production

A new study published in the journal Inflammation indicates that in myeloid…

Cytokines & Brain

Disruption of Brain TNF Homeostasis Elicits Maladaptive Alterations Producing Chronic Pain

Neuroendocrine Immune Implications in Rheumatoid Arthritis and Polymyalgia Rheumatica: Past and Present Unresolved Issues and Optimising Glucocorticoid Treatment

Microglia: gatekeepers for neuropathic pain

The Cross-talk between the Dopaminergic System and Innate Immunity: An Evolving Concept

An Evolving Concept: The Pathologic Level of Brain TNF is a Therapeutic Target for Chronic Pain Treatment

The selfishness of the brain and immune systems provoke energy deficiency in aging and chronic inflammation

Brain Superautoantigens: Connections between Immune and Neural Repertoires

Understanding the Role of Inflammation in Fatigue Requires Multidimensional Assessments

2017 in Review: New Advances in Neuroendocrine Immunology

Raloxifene and Two New Selective Estrogen Receptor Modulators (SERMs) Inducing M2-Macrophage Shift and High IL-10 and IL-1Ra Production

Disruption of Brain TNF Homeosta…

The Central Inflammatory Reflex:…

β2-Adrenergic Agonists for Parkinson’s Disease: Repurposing Drugs at the Crossroad of the Brain and the Immune System

Acid Sensing By Sensory Neurons in Infla…

ATP as a Neuromedia…

Endogenous Catecholamines in Immune Cell…

Sex Hormones and Im…

Sex Steroids Hormones and Autoimmune Dis…

Neuroendocrine-Immune Interactions in Lu…

The 20 Most-Read BrainImmune Stories of 2018

Evidence that Microglia in Fibromyalgia is Hypersensitive and Overproducing TNF-α

Cognitive Decline and Alzheimer’s Linked to Low Systemic REST Levels and Deficient Stress Protection of the Aging Brain

The Chemokines CX3CL1 and IL-8 May Be Implicated in the Pathogenesis of Fibromyalgia

IL-35 Contributing to Immune Tolerance in Normal Pregnancy

Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma

The Therapeutic Potential of Secukinumab in Rheumatic Diseases

Job Burnout Reaching an Unprecedented Level and Half of US Physicians Experiencing Professional Burnout

Stress & Organ Specific Autoimmunity: A Complex Interrelationship

Meetings

Lessons Learned from the Hibernating Brown Bears

The Evolving Link between Social Media Addiction and Depression in Young Adults

Bridging Neurosciences and Immunology – An Overview

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