BrainImmune: Brain-Immune Interactions Resource

Sympathetic Nervous System Dysfunction in Rheumatoid Arthritis: Brief Overview

Rheumatoid arthritis (RA) is an autoimmune condition characterized by chronic inflammation occurring locally within the synovial joints and systemically. Accumulating evidence supports an important role of the sympathetic nervous system in the pathophysiology of RA, both as a cause and consequence of inflammation. Acute sympathetic

Parkinson’s Disease: Peripheral Immunity Links Neurodegeneration and the Intestinal Microbiota

Commentary By Marco Cosentino, Cristoforo Comi and Franca Marino On the study by Matheoud D et al., Nature, 2019; 571(7766):565-569; Doi: 10.1038/s41586-019-1405-y, Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1-/- mice. Parkinson’s disease (PD) is a chronic neurodegenerative disease affecting 7 to 10 million people…

The Emerging Role of Neuro-Immune Synapses and the Immunological Homunculus in the Context of the Systematic Lymphoid Organs Innervation

Evolving concept By Clemens Wülfing, Fenja Amrei Schuran, Inga Hölge, Julia Urban, Jasmin Oehlmann and Hauke Simon Günther Nearly all body tissues are connected to the central nervous system through the axonal terminals of neurons. But with regard to lymphoid organs, this direct innervation, its…

Neuroendocrine Immune Implications in Rheumatoid Arthritis and Polymyalgia Rheumatica: Past and Present Unresolved Issues and Optimising Glucocorticoid Treatment

Editorial Introduction and background The dramatic effects of cortisone and pituitary adrenocortical hormone therapy on rheumatoid arthritis (RA) were discovered almost seven decades ago (1) and even longer for the significant disease amelioration during pregnancy as reported by Hench in 1938 (2). However, major questions

The Cross-talk between the Dopaminergic System and Innate Immunity: An Evolving Concept

Evolving Concept Dopamine (DA) is a well-known neurotransmitter in the central nervous system (CNS). An increasing body of evidence, however, indicates that DA is also an important communication mediator at the neural-immune interface [1-3]. Most research and studies to date have put the emphasis on

An Evolving Concept: The Pathologic Level of Brain TNF is a Therapeutic Target for Chronic Pain Treatment

Evolving Concept Chronic pain is a serious healthcare dilemma with many treatment options available, such as antidepressants, non-steroidal anti-inflammatory drugs, opioids, and anticonvulsants; nevertheless, chronic pain presently is not appropriately managed. A fundamental reason for the lack of effective treatment is that none of these

Pain neurons & S. pyogenes infection Neural Suppression Neutralizes F…
Perispinal Etanercept & Stroke Treatment Australian Government Advances S…
Growth Hormone & Pneumococcal Disease Are children with growth hormone…
Teach the T Cells Teach the T Cells: Learned Immun…
Macrophages & Heart Electrical Conduction First Evidence that Macrophages …

New Concepts

Microglia: gatekeepers for neuropathic pain

Sympathetic Nervous System Dysfunction in Rheumatoid Arthritis: Brief Overview

Parkinson’s Disease: Peripheral Immunity Links Neurodegeneration and the Intestinal Microbiota

The Emerging Role of Neuro-Immune Synapses and the Immunological Homunculus in the Context of the Systematic Lymphoid Organs Innervation

Neuroendocrine Immune Implications in Rheumatoid Arthritis and Polymyalgia Rheumatica: Past and Present Unresolved Issues and Optimising Glucocorticoid Treatment

The Cross-talk between the Dopaminergic System and Innate Immunity: An Evolving Concept

An Evolving Concept: The Pathologic Level of Brain TNF is a Therapeutic Target for Chronic Pain Treatment

Microglia: gatekeepers for neuropathic pain

2017 in Review: New Advances in Neuroendocrine Immunology

Parkinson’s Disease: Peripheral Immunity Links Neurodegeneration and the Intestinal Microbiota

Disruption of Brain TNF Homeosta…

T Cell and Antigen Presenting Ce…

The Central Inflammatory Reflex:…

Production of immunomodulatory and anti-inflammatory neuropeptides by specific gut microbiota genera: in silico evidence

Acid Sensing By Sensory Neurons in Infla…

Endogenous Catecholamines in Immune Cell…

Sex Steroids Hormones and Autoimmune Dis…

Neuroendocrine-Immune Interactions in Lu…

The 20 Most-Read BrainImmune Stories of 2018

Evidence that Microglia in Fibromyalgia is Hypersensitive and Overproducing TNF-α

Cognitive Decline and Alzheimer’s Linked to Low Systemic REST Levels and Deficient Stress Protection of the Aging Brain

The Chemokines CX3CL1 and IL-8 May Be Implicated in the Pathogenesis of Fibromyalgia

IL-35 Contributing to Immune Tolerance in Normal Pregnancy

Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma

The Therapeutic Potential of Secukinumab in Rheumatic Diseases

Job Burnout Reaching an Unprecedented Level and Half of US Physicians Experiencing Professional Burnout

Stress & Organ Specific Autoimmunity: A Complex Interrelationship

Psychosocial Stress and Chronic Viral Hepatitis

Lessons Learned from the Hibernating Brown Bears

The Evolving Link between Social Media Addiction and Depression in Young Adults

Bridging Neurosciences and Immunology – An Overview

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