BrainImmune: Trends in Neuroendocrine Immunology | New concepts & viewpoints in brain–immune interactions, stress and immunity, the interface of neuroscience & immunology on BrainImmune

Neuroendocrine Immune Implications in Rheumatoid Arthritis and Polymyalgia Rheumatica: Past and Present Unresolved Issues and Optimising Glucocorticoid Treatment

Neuroendocrine Immune Implications in Rheumatoid Arthritis and Polymyalgia Rheumatica: Past and Present Unresolved Issues and Optimising Glucocorticoid Treatment

Editorial Introduction and background The dramatic effects of cortisone and pituitary adrenocortical hormone therapy on rheumatoid arthritis (RA) were discovered almost seven decades ago (1) and even longer for the significant disease amelioration during pregnancy as reported by Hench in 1938 (2). However, major questions

Microglia: gatekeepers for neuropathic pain

Microglia: gatekeepers for neuropathic pain

Evolving Concepts Introduction Where acute pain protects an individual from further damage, chronic pain serves no adaptive purpose. Approximately 1 in 5 people suffer from chronic pain, which exacts a substantial toll on the both the individual and on national economies [1–3]. Chronic pain can

The Cross-talk between the Dopaminergic System and Innate Immunity: An Evolving Concept

The Cross-talk between the Dopaminergic System and Innate Immunity: An Evolving Concept

Evolving Concept Dopamine (DA) is a well-known neurotransmitter in the central nervous system (CNS). An increasing body of evidence, however, indicates that DA is also an important communication mediator at the neural-immune interface [1-3]. Most research and studies to date have put the emphasis on

An Evolving Concept: The Pathologic Level of Brain TNF is a Therapeutic Target for Chronic Pain Treatment

An Evolving Concept: The Pathologic Level of Brain TNF is a Therapeutic Target for Chronic Pain Treatment

Evolving Concept Chronic pain is a serious healthcare dilemma with many treatment options available, such as antidepressants, non-steroidal anti-inflammatory drugs, opioids, and anticonvulsants; nevertheless, chronic pain presently is not appropriately managed. A fundamental reason for the lack of effective treatment is that none of these

The selfishness of the brain and immune systems provoke energy deficiency in aging and chronic inflammation

The selfishness of the brain and immune systems provoke energy deficiency in aging and chronic inflammation

Evolving Concepts “I feel exhausted with mental stress and with systemic inflammation, but why?” In recent publications [1-5], in highly active chronic inflammatory diseases, I demonstrated how energy shortage due to an active and selfish immune system can stimulate a plethora of common signs and

Brain Superautoantigens: Connections between Immune and Neural Repertoires

Brain Superautoantigens: Connections between Immune and Neural Repertoires

Opinion Article Introduction Although human cells express a quasi-infinite number of potential autoantigens, only a limited range of the human “self” antigen library is actually targeted by pathological autoimmunity. Accordingly, the clinical expression of human autoimmunity is essentially restricted to relatively few stereotyped disorders including

Pain neurons & S. pyogenes infection Neural Suppression Neutralizes F…
Perispinal Etanercept & Stroke Treatment Australian Government Advances S…
Growth Hormone & Pneumococcal Disease Are children with growth hormone…
Teach the T Cells Teach the T Cells: Learned Immun…
PNIRS & GEBIN Conference PNIRS and GEBIN Conference in 20…

EvolvingConcepts

Understanding the Role of Inflammation in Fatigue Requires Multidimensional Assessments

Understanding the Role of Inflammation in Fatigue Requires Multidimensional Assessments

Evolving concepts Introduction “I am tired”. What…

Pro-Inflammatory Th17 Cells and Glucocorticoid Resistance: Implications for Chronic Inflammatory Diseases and Their Treatment

Pro-Inflammatory Th17 Cells and Glucocorticoid Resistance: Implications for Chronic Inflammatory Diseases and Their Treatment

Evolving Concepts Summary Th17 have heterogeneous phenotypes…

EditorialsOpinions

2017 in Review: New Advances in Neuroendocrine Immunology

2017 in Review: New Advances in Neuroendocrine Immunology

Editorial In 2017, we witnessed further rapid growth in the vast interdisciplinary…

Raloxifene and Two New Selective Estrogen Receptor Modulators (SERMs) Inducing M2-Macrophage Shift and High IL-10 and IL-1Ra Production

Raloxifene and Two New Selective Estrogen Receptor Modulators (SERMs) Inducing M2-Macrophage Shift and High IL-10 and IL-1Ra Production

A new study published in the journal Inflammation indicates that in myeloid…

Cytokines& Brain

Disruption of Brain TNF Homeostasis Elicits Maladaptive Alterations Producing Chronic Pain

Disruption of Brain TNF Homeosta…

The Central Inflammatory Reflex: Afferent Vagal and Central Brain Stimulations Control Experimental Arthritis

The Central Inflammatory Reflex:…

BRAINIMMUNE COMMENTARIES

β2-Adrenergic Agonists for Parkinson’s Disease: Repurposing Drugs at the Crossroad of the Brain and the Immune System

β2-Adrenergic Agonists for Parkinson’s Disease: Repurposing Drugs at the Crossroad of the Brain and the Immune System

Commentary On the study by Mittal S, Science, 2017; 357(6354):891-898. doi: 10.1126/science.aaf3934 β2-Adrenoreceptor is a regulator…

Neural Control of Immunity

Acid Sensing By Sensory Neurons in Inflammation

Acid Sensing By Sensory Neurons in Infla…

Overview article Chronic inflammatory conditions, such as rheumatoid arthritis (RA), are characterized…

ATP as a Neuromediator at the Brain-Immune Interface

ATP as a Neuromedia…

Overview article The purinergic signaling system,…

Influence of the Sympathetic Nervous System on Regulatory T cells: Another Link in Neuro-Immune Interactions

Influence of the Sy…

Overview article Homeostatic control of the…

Hormones and Immunity

Endogenous Catecholamines in Immune Cells: Discovery, Functions And Clinical Potential as Therapeutic Targets

Endogenous Catecholamines in Immune Cell…

Overview article The catecholamines dopamine, noradrenaline and adrenaline are well established neurotransmitters…

Sex Hormones and Immunoregulation

Sex Hormones and Im…

Overview article The sexual dimorphism in…

Nerve Growth Factor and Inflammation: A Complex Bidirectional Interaction

Nerve Growth Factor…

Overview article The nervous and immune…

Neuroendocrine Immunology of Autoimmunity

Sex Steroids Hormones and Autoimmune Disease Activity

Sex Steroids Hormones and Autoimmune Dis…

Overview article Females display an increased incidence of autoimmune diseases, with a…

Pregnancy and Rheumatoid Arthritis

Pregnancy and Rheum…

Overview article Rheumatoid arthritis (RA) is…

Neuro-Immune Dysfunction in Human Diseases

Neuroendocrine-Immune Interactions in Lung Inflammatory Diseases

Neuroendocrine-Immune Interactions in Lu…

Overview article Inflammation is the body’s response to insults. During inflammation, various…

Aging Alters Sympathetic Noradrenergic Innervation and Immune Reactivity in the Lymphoid Organs: Strategies to Reverse Neuro-Immune Senescence

Aging Alters Sympat…

Overview article Current therapeutic strategies in…

The 20 Most-Read BrainImmune Stories of 2018

The 20 Most-Read BrainImmune Stories of 2018

Evidence that Microglia in Fibromyalgia is Hypersensitive and Overproducing TNF-α

Evidence that Microglia in Fibromyalgia is Hypersensitive and Overproducing TNF-α

Cognitive Decline and Alzheimer’s Linked to Low Systemic REST Levels and Deficient Stress Protection of the Aging Brain

Cognitive Decline and Alzheimer’s Linked to Low Systemic REST Levels and Deficient Stress Protection of the Aging Brain

The Chemokines CX3CL1 and IL-8 May Be Implicated in the Pathogenesis of Fibromyalgia

The Chemokines CX3CL1 and IL-8 May Be Implicated in the Pathogenesis of Fibromyalgia

IL-35 Contributing to Immune Tolerance in Normal Pregnancy

IL-35 Contributing to Immune Tolerance in Normal Pregnancy

Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma

Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma

The Therapeutic Potential of Secukinumab in Rheumatic Diseases

The Therapeutic Potential of Secukinumab in Rheumatic Diseases

Job Burnout Reaching an Unprecedented Level and Half of US Physicians Experiencing Professional Burnout

Job Burnout Reaching an Unprecedented Level and Half of US Physicians Experiencing Professional Burnout

Stress &Immunity

Stress & Organ Specific Autoimmunity: A Complex Interrelationship

Stress & Organ Specific Autoimmunity: A Complex Interrelationship

Overview Article The evidence for stress contributing…

Features& Faces

Lessons Learned from the Hibernating Brown Bears

Lessons Learned from the Hibernating Brown Bears

“The Mind-Gut Connection“, written by Emeran Mayer, M.D., demonstrates his vast experience…

The Evolving Link between Social Media Addiction and Depression in Young Adults

The Evolving Link between Social Media Addiction and Depression in Young Adults

Recently, in the journal Pediatrics, Elizabeth Hoge, MD, David Bickham, PhD and…

Bridging Neurosciences and Immunology – An Overview

Bridging Neurosciences and Immunology – An Overview

Historical Perspectives The brain and the immune system, or the “supersystems”, a…

Bartolomeo Eustachius and the Discovery of Adrenal Glands

Bartolomeo Eustachius and the Discovery of Adrenal Glands

Historical Perspectives Bartolomeo Eustachio was born in 1524 in San Severino…